Actively Recruiting
Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI
Led by China-Japan Friendship Hospital · Updated on 2022-09-26
2500
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an multicenter, randomized, controlled, parallel group study. ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(HTB) will be allocated to one of the following: intrathrombus thrombolysis or manual aspiration thrombectomy during primary percutaneous coronary intervention(PPCI).
CONDITIONS
Official Title
Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with myocardial ischemia symptoms lasting 30 minutes or more
- Definite ECG changes indicating STEMI (ST elevation >0.1 mV in two limb leads or >0.2 mV in two precordial leads)
- Referred for primary percutaneous coronary intervention (PPCI)
- Within 12 hours of symptom onset, or 12-24 hours with persistent symptoms, hemodynamic instability, or fatal arrhythmia
- High thrombus burden defined by TIMI thrombus grade 3 or 4 after angiography, or grade ≥3 after guidewire crossing or predilation if initial grade 5
- Provided informed consent
You will not qualify if you...
- Rescue PCI after systemic thrombolysis
- Previous coronary artery bypass graft (CABG) surgery
- Life expectancy less than 1 year
- Active bleeding in past 6 months, bleeding disorders, or prone to bleeding
- Serious liver or kidney dysfunction
- Pregnancy or breastfeeding
- Uncontrolled high blood pressure (greater than 180/100 mmHg)
- Previous hemorrhagic or ischemic stroke within past 3 months
- Cardiogenic shock or requiring cardiopulmonary resuscitation
- Unable to provide informed consent or complete follow-up
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
Research Team
Z
Zhen Zhang, Doctor
CONTACT
Z
Zhaoxue Sheng, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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