Comparing Intravascular Imaging-Guided and Angiography-Guided PCI for Drug-Eluting Stent In-Stent Restenosis in Adults

What this Trial Is About

This research aims to compare the clinical and angiographic results in patients with drug-eluting stent in-stent restenosis DES-ISR who undergo repeat percutaneous coronary intervention PCI using either intravascular imaging or angiographic guidance. DES-ISR is a condition where a previously placed drug-eluting stent narrows again, leading to complex mechanisms that can affect long-term heart health. Intravascular imaging techniques like OCT or IVUS provide detailed information about the artery and lesion, which may influence treatment choices and outcomes. Participants receive repeat PCI using one of two approaches intravascular imaging-guided PCI or angiography-guided PCI for lesions diagnosed with ISR. The study compares these two guidance methods to evaluate their efficacy and safety in treating DES-ISR. Treatment selection is based on detailed vessel and lesion characteristics obtained through these imaging methods. During the study, participants will be monitored for major adverse cardiac events MACE over three years, which is the primary outcome. Additional measurements taken during the procedure include stent expansion and minimal stent area MSA. The study involves follow-up to assess clinical outcomes and angiographic data quality, ensuring safety and effectiveness of the imaging guidance methods in PCI for DES-ISR patients.

Intravascular Imaging-Guided Versus Angiography- Guided PCI in Patients With DES-ISR