Actively Recruiting
Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2024-09-25
1100
Participants Needed
8
Research Sites
180 weeks
Total Duration
On this page
Sponsors
M
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor
L
Laval University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.
CONDITIONS
Official Title
Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Scheduled for elective cardiac surgery
- Stable condition before surgery
- Undergoing aorto-coronary bypass with or without one valve replacement
You will not qualify if you...
- Surgeon refusal to participate
- Surgeon or anesthesia requests late extubation
- Use of intra-aortic balloon pump
- Use of mechanical cardiac support
- Sensitivity to acetaminophen
- Current active psychiatric treatment
- Alzheimer's disease
- Seizure within the previous 6 months
- Recent history of alcohol misuse
- Cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z4
Active, Not Recruiting
2
University of Manitoba
Winnipeg, Manitoba, Canada, R3T2N2
Actively Recruiting
3
Trillium Health Centre
Mississagua, Ontario, Canada, L5B2V2
Not Yet Recruiting
4
University of Ottawa
Ottawa, Ontario, Canada, K1N6N5
Not Yet Recruiting
5
Sunnybroook Health Centre
Toronto, Ontario, Canada, M4N3M5
Not Yet Recruiting
6
McGill Universtiy Health Centre
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
7
Universite Montreal
Montreal, Quebec, Canada, R3T2N2
Actively Recruiting
8
University of Laval
Québec, Quebec, Canada, G1V0A6
Actively Recruiting
Research Team
S
Sheldon Magder, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here