Comparison of Intravenous Contrast CT and Non-Contrast CT in Adults With Acute Abdomen and Reduced Kidney Function

What this Trial Is About

Researchers are evaluating the use of intravenous IV contrast-enhanced computed tomography CT compared to native CT without contrast in adults with acute abdominal pain who have impaired kidney function. This study addresses concerns about the risk of post-contrast acute kidney injury PC-AKI in patients with reduced renal function, aiming to provide clearer evidence through a randomized controlled trial. The trial focuses on patients with an estimated glomerular filtration rate eGFR between 15 and 45 mlmin1.73 m2 who require emergency abdominal or body CT scans. Participants are randomly assigned to one of two groups one receiving abdominal or body CT with IV contrast, and the other receiving abdominal or body CT without IV contrast native CT. This open-label trial is conducted at multiple centers, comparing the effects and outcomes of these two imaging methods in patients with impaired kidney function. The study is designed to determine if the use of IV contrast affects mortality or the need for renal replacement therapy. During the study, researchers will monitor participants for outcomes including all-cause mortality and renal replacement therapy within 90 days after the CT scan. Additional evaluations include measuring acute kidney injury within 72 hours, any organ failure within 48 hours, hospital-free days within 90 days, and the time from CT to definitive treatment during the hospital stay. Participants will be followed closely after their CT scan to assess these outcomes and ensure safety throughout the study period.

Intravenous Contrast Computed Tomography Versus Native Computed Tomography in Patients With Acute Abdomen and Impaired Renal Function