Comparing Intravenous and Perineural Ondansetron for Pain and Nausea Prevention in Laparoscopic Sleeve Gastrectomy

What this Trial Is About

Researchers are evaluating the effects of ondansetron, a drug commonly used to manage nausea and vomiting after surgery, in patients undergoing laparoscopic sleeve gastrectomy, a weight loss surgery for obesity. This study compares the anti-nausea and pain-relief effects of ondansetron given through an intravenous IV route versus delivered perineurally as part of a nerve block during surgery. The goal is to see if the perineural method is not worse than IV treatment for preventing nausea and vomiting and if it can better reduce postoperative pain. Participants will receive a para-gastric autonomic neural blockade during surgery, where a local anesthetic mixture is injected near nerves around the stomach. One group will get ondansetron mixed with the anesthetic injected perineurally, along with a saline IV injection. The other group will receive ondansetron IV with saline mixed in the nerve block. The nerve block solution contains bupivacaine and either ondansetron or saline. The IV injections are given slowly over 15 minutes. This randomized, double-blind trial will test these two methods to compare effects. During the study, researchers will measure vomiting in the first 8 hours after surgery and pain levels at 1 hour post-surgery using a pain rating scale. Further assessments of nausea, vomiting, pain, use of rescue medications, opioid doses, and patient satisfaction will be done up to 24 hours after surgery. Participants will be monitored closely for safety and changes in symptoms. The total participation duration covers the immediate postoperative period, with important outcomes focused on the first day after surgery.

Intravenous Versus Perineural Ondansetron for Laparoscopic Sleeve Gastrectomy