Actively Recruiting
Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain
Led by University of Chicago · Updated on 2025-11-10
116
Participants Needed
1
Research Sites
235 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Post-operative pain and lower urinary tract symptoms are common following ureteroscopy in the treatment of stone disease. The use of bupivacaine as a topical pain medication is used routinely for other urologic procedures, however, to date there are no studies that have rigorously investigated the effect of instilling bupivacaine in the bladder following ureteroscopy. This is a randomized study that will investigate the effect of instilling bupivacaine in the bladder following routine ureteroscopy, laser lithotripsy and ureteral stenting in the treatment of stone disease. Compared to a placebo of Normal Saline, our study hypothesizes that administration of topical bupivacaine in the bladder will decrease post-operative pain and lower urinary tract symptoms while improving quality of life in the early post-operative period.
CONDITIONS
Official Title
Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form provided
- Willingness to comply with all study procedures and availability for the entire study duration
- Male or female aged 18 years or older
- Diagnosis of nephrolithiasis planned for flexible or semi-rigid ureteroscopy with ureteral stenting
You will not qualify if you...
- Presence of Foley catheterization
- History of allergy to bupivacaine
- Undergoing antegrade ureteroscopy
- Having a transplant or ectopic kidney
- History of ureteral or bladder reconstruction
- Pregnancy
- Receiving dialysis
- Surgical complications such as significant bleeding, ureteral perforation, or urothelial damage
- Suspicion of untreated urinary tract infection
- History of pelvic radiation
- Neurologic disease causing neurogenic bladder dysfunction
- History of chronic pain conditions like fibromyalgia, interstitial cystitis, or opioid abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
L
Luke Reynolds, MD
CONTACT
L
Leila Yazdanbakhsh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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