Actively Recruiting
Intravital Microscopy in Human Solid Tumors
Led by Mayo Clinic · Updated on 2025-12-11
85
Participants Needed
1
Research Sites
395 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.
CONDITIONS
Official Title
Intravital Microscopy in Human Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 or less
- Measurable tumor requiring surgical removal in the operating room
- Tumor types include gastric, pancreatic, hepatobiliary, colorectal, sarcoma, brain, or breast cancer, either primary or metastatic
- Ability to understand the investigational nature of the study and provide written informed consent
- Negative skin prick test for fluorescein sensitivity before surgery
You will not qualify if you...
- Uncontrolled illness such as active infection, heart failure, unstable angina, arrhythmia, or psychiatric/social issues
- Kidney dysfunction with glomerular filtration rate below 45
- Liver dysfunction with Child-Pugh score above 5 or liver tests 1.5 times above normal
- Known allergy or positive skin test to fluorescein
- Pregnant or breastfeeding women
- Unable or unwilling to follow study procedures
- Conditions making patient unsuitable for surgery or requiring further cardiac evaluation
- Any condition that excludes surgical tumor removal as standard care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
Research Team
E
Emmanuel M Gabriel, M.D., Ph.D.
CONTACT
M
Michael B Wallace, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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