Actively Recruiting
Invasive Candidiasis in Critical Care
Led by University Hospital Ostrava · Updated on 2025-06-05
100
Participants Needed
2
Research Sites
189 weeks
Total Duration
On this page
Sponsors
U
University Hospital Ostrava
Lead Sponsor
U
University Hospital, Motol
Collaborating Sponsor
AI-Summary
What this Trial Is About
The combination of acute phase marker monitoring and the "T2Candida" assay (name of the test) will represent an acceleration of the identification of the causative agent of mycotic infection, a significant improvement in the specificity and positive predictive value of this strategy in the diagnosis of invasive candidiasis and candidemia in ICU patients, thereby improving the clinical condition of patients and reducing the cost of specific antifungal therapy.
CONDITIONS
Official Title
Invasive Candidiasis in Critical Care
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Critically ill patients
- New onset sepsis
- Body temperature above 38�B0C according to The Third Consensus Definitions for Sepsis and Septic Shock
- Colonization with Candida species from more than one non-sterile site
- Body temperature above 38�B0C despite five days of broad-spectrum antibiotic therapy with at least one risk factor: abdominal surgery, secondary peritonitis, pancreatitis, central venous catheter insertion, total parenteral nutrition, dialysis, steroid therapy, immunosuppressive therapy, or liver transplantation
- Microbiological test results reviewed and categorized based on Candida isolation from at least two non-sterile sites (plus or minus three days) and presence of alternative microbiological diagnosis
You will not qualify if you...
- Not signing informed consent for study participation
- Receiving antifungal therapy prior to collection of biological material required for the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia, 708 52
Actively Recruiting
2
University Hospital Motol
Prague, Czechia, 150 06
Actively Recruiting
Research Team
J
Jiří Hynčica
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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