Actively Recruiting
Investigating the Biomarkers in Tumor and Peripheral Blood to Evaluate the Efficacy of Cancer Immunotherapy in Chest Cancer Patients
Led by Zhao Jun · Updated on 2025-01-24
50
Participants Needed
1
Research Sites
232 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the impact of immunotherapy on the immune status of tumor microenvironment and peripheral blood of chest cancer patients. To do so, the investigators plan to collect tumor tissue and peripheral blood samples before and after immunotherapy, and use single-cell RNA sequencing, Multiplex immunohistochemistry, and flow cytometry. The investigators will analyze changes in the proportion of cancer cell-specific T-cell subpopulations related to treatment response before and after therapy, and seek biological markers that can predict the efficacy of immunotherapy.
CONDITIONS
Official Title
Investigating the Biomarkers in Tumor and Peripheral Blood to Evaluate the Efficacy of Cancer Immunotherapy in Chest Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a pathological diagnosis of lung cancer or esophageal cancer who have agreed to receive PD-1/PD-L1 antibody immunotherapy
- Age between 18 and 80 years old
- ECOG PS score of 0 or 1
- Adequate organ and bone marrow function
- Anticipated survival time of at least 12 weeks
- Willing and able to provide written informed consent
You will not qualify if you...
- Patients with hematogenic infectious diseases, such as HIV, hepatitis B or hepatitis C
- Patients with tumor emergencies that require immediate treatment
- Poor vascular conditions
- Abnormal coagulation function or receiving anticoagulant or thrombolytic therapy
- Patients with psychiatric disorders or severe mental illnesses
- Patients who have difficulty communicating or are unable to be followed up for a long time
- Other situations that are not suitable for inclusion in the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The first affiliated hospital of soochow university
Suzhou, Jiangsu, China, 215000
Actively Recruiting
Research Team
M
Mi Liu
CONTACT
J
Jun Zhao
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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