Actively Recruiting
Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis
Led by Wayne State University · Updated on 2022-06-06
80
Participants Needed
1
Research Sites
471 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators intend to examine the effects of ocrelizumab use in African American multiple sclerosis disease course compared to Caucasian disease course utilizing imaging measures with magnetic resonance imaging (MRI) and optical coherence tomography angiography (OCT-A)..
CONDITIONS
Official Title
Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who have chosen to start ocrelizumab and for whom ocrelizumab is determined to be the most appropriate standard-of-care disease modifying therapy by the treating neurologist
- May be treatment naive or had suboptimal response to no more than one disease modifying therapy after an adequate course of treatment (6+ months)
- Age 18 to 60 years old
- Self-identified as African American or Caucasian
- Clinically definite relapsing remitting multiple sclerosis per 2017 revised McDonald criteria
- Expanded Disability Status Scale (EDSS) score from 0 to 6 inclusive at baseline visit
- Able to give informed consent
- Able to undergo MRI scans
You will not qualify if you...
- Treatment with another monoclonal antibody such as natalizumab, alemtuzumab, or daclizumab
- Failed two or more disease modifying therapies
- Treatment with immunosuppressant agents like chemotherapeutic drugs
- Claustrophobia
- Allergy to contrast agents
- Significant medical problems interfering with study conduct as determined by principal investigator
- Relapse or corticosteroid use within 30 days prior to baseline visit
- Pregnancy
- History of kidney or liver insufficiency
- History of malignancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Wayne State University
Detroit, Michigan, United States, 48201
Actively Recruiting
Research Team
Z
Zahid Latif
CONTACT
K
Kelly Jia
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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