Meat Consumption, Cognitive Function and Disorders: A Systematic Review with Narrative Synthesis and Meta-Analysis.
Huifeng Zhang, Laura Hardie, Areej O Bawajeeh...
https://pubmed.ncbi.nlm.nih.gov/32456281/Actively Recruiting
Led by University of Nebraska Lincoln · Updated on 2026-05-29
240
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating whether eating more beef can improve cognitive function and brain health in healthy younger adults aged 19 to 24. The study aims to see if higher beef consumption leads to better scores on cognitive tests, improved quality of life, and better brain function using brain imaging. It also looks at effects on memory, executive function, psychological well-being, and sleep quality. Participants will be randomly assigned to one of two groups for a 12-week dietary intervention. The experimental group will consume five 5-ounce portions of ready-to-eat lean beef weekly, while the control group will consume five 1-ounce portions weekly. Both groups receive frozen beef meals to prepare and consume alongside their regular diet, and compliance is monitored with weekly surveys. Participants will visit the study site weekly to pick up their frozen beef meals and complete brief consumption surveys. Before and after the 12-week intervention, they will undergo brain MRI scans, complete cognitive and psychological questionnaires, perform neuropsychological tasks, and have blood drawn. The researchers will measure various cognitive and health outcomes to assess the impact of increased beef consumption on brain health and cognitive abilities.
CONDITIONS
Investigating the Effects of Beef Consumption on Cognitive and Brain Health
D
Douglas Schultz, PhD
A
Aron Barbey, PhD
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University of Nebraska Lincoln
Lead Sponsor
National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | 5-oz Beef Portion (Experimental) | 1-oz Beef Portion (Control) |
|---|---|---|
| What it is | Participants receive five 5-oz frozen, ready-to-eat beef portions (one cap steak strip, one shredded chuck roast, one petite shoulder medallion, and two ground beef crumbles) per week for 12 weeks. | Participants receive five 1-oz frozen, ready-to-eat beef portions (one cap steak strip, one shredded chuck roast, one petite shoulder medallion, and two ground beef crumbles) per week for 12 weeks. |
| Role in trial | Tests the cognitive and brain health effects of increased beef consumption compared to lower beef intake. | Serves as the control group with minimal beef intake to compare with the higher beef portion group. |
| Primary use or measurement | Used to evaluate whether higher ready-to-eat beef intake improves cognitive outcomes and brain health measures over 12 weeks. | Used as a low-beef-intake control to evaluate cognitive outcomes and brain health measures over 12 weeks. |
| How it is given or performed | Participants are provided with five frozen, 5-oz ready-to-eat beef portions per week. They consume one portion on each of five days as part of their diet for 12 weeks. | Participants are provided with five frozen, 1-oz ready-to-eat beef portions per week. They consume one portion on each of five days as part of their diet for 12 weeks. |
| Evidence status | The effects of higher beef intake on cognitive ability are presently unknown in randomized trials. A meta-analysis found limited and mixed evidence linking meat consumption with cognitive outcomes in adults; studies vary in meat type, population, and design. | The cognitive effects of lower beef intake (1-oz portions) as a control in young, healthy adults are not established by external literature. No specific guideline recommends this intake as a standard cognitive-health comparator. |
| Important limitations | Trial population is healthy young adults, not those with cognitive impairment. Short-term intervention (12 weeks) may not reflect long-term effects of dietary beef on cognition. External evidence is limited and variable across study designs. | This arm serves as a lower-beef-intake control but does not compare with diets that exclude beef entirely. Short duration and specific age group may limit generalizability to other populations or longer-term cognitive health. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants follow a 12-week dietary intervention consuming ready-to-eat beef in frozen packages, with portion sizes depending on group assignment. The experimental group consumes 5 portions per week weighing 5 ounces each, and the control group consumes 5 portions per week weighing 1 ounce each. Compliance is monitored through weekly surveys.
Weekly visits to complete surveys and assessments
Duration - At the start and end of the 12-week intervention
Participants complete comprehensive assessments including MRI brain scans, cognitive and psychological questionnaires, neuropsychological tasks, and blood draws before and after the intervention to evaluate cognitive function and brain health.
2 visits (in-person assessments at baseline and after 12 weeks)
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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Huifeng Zhang, Laura Hardie, Areej O Bawajeeh...
https://pubmed.ncbi.nlm.nih.gov/32456281/Piril Hepsomali, John A Groeger
https://pubmed.ncbi.nlm.nih.gov/34083695/University of Nebraska Lincoln
Lead Sponsor
National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Collaborating Sponsor