Actively Recruiting
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
Led by Massachusetts Institute of Technology · Updated on 2025-12-03
50
Participants Needed
1
Research Sites
59 weeks
Total Duration
On this page
Sponsors
M
Massachusetts Institute of Technology
Lead Sponsor
M
Massachusetts General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder (SAD).
CONDITIONS
Official Title
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability and willingness to provide written informed consent
- Sufficiently fluent in English to participate in the trial
- Between 18 and 55 years of age (inclusive)
- Right-hand dominant
- Current medications are stable for past 30 days with no changes to dose or frequency
- Negative result on pregnancy test (if female)
- Negative result on urine drug screening
- Liebowitz Social Anxiety Scale (LSAS) score of 60 or higher
You will not qualify if you...
- History of bipolar disorder, schizophrenia, psychosis, or delusional disorders
- History of eating disorder within past 6 months
- History of any traumatic brain injury
- Currently diagnosed with diabetes mellitus
- Presence of severe medical illness preventing study completion
- Significant neurological illness or cognitive dysfunction such as seizures or dementia
- History of substance use disorder within past 6 months except nicotine and caffeine
- Use of any cannabis-containing products in past 30 days
- Use of benzodiazepines in past 2 weeks
- Use of alpha- or beta-blockers in past week
- History of claustrophobia
- Contraindications for MRI such as shrapnel
- Any other medical condition that may interfere with study procedures
- Use of medications strongly interacting with cannabidiol
- History of liver disease
- History of hypersensitivity to cannabinoids
- History of hypersensitivity to sesame seed oil
- Currently breastfeeding (if female)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts Institute of Technology
Cambridge, Massachusetts, United States, 02139
Actively Recruiting
Research Team
O
Omar Rutledge, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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