Actively Recruiting
Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Led by National Taiwan University Hospital · Updated on 2024-08-19
120
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall. Transcranial direct current stimulation (tDCS) is an emerging non-invasive brain stimulation technology that has great potential to be applied to neurorehabilitation; however, the optimization of its applications still needs further studies. The aims of this project are to compare the effects of anodal tDCS (AtDCS) applied to the primary motor cortex (M1) contralateral to the moving leg (cM1), posterior parietal cortex (PPC) contralateral to the moving leg (cPPC), and cerebellar cortex (CBM) ipsilateral to the moving leg (iCBM) on motor learning, motor adaptation, and brain connectivity in healthy middle-aged and older adults and hemiparetic patients with chronic subcortical stroke.
CONDITIONS
Official Title
Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 80 years old
- Intact cognitive function with MMSE score of 27 or higher
- Normal ankle strength and range of motion (dorsiflexion 30 degrees or less; plantarflexion 45 degrees or more)
- Corrected far vision of 0.8 or better and uncorrected near vision of 0.04 or better
- For stroke patients: first-ever subcortical stroke at least 3 months ago affecting one side of the brain
- Hemiplegic or hemiparetic condition for stroke patients
- No spatial neglect for stroke patients
- Ability to actively move affected ankle with specified range of motion
- No excessive spasticity or severe contracture in affected leg
- Mild to moderate disability
- Ability to walk independently or under supervision without assistance
You will not qualify if you...
- Any contraindications for MRI or tDCS
- Serious or uncontrolled systemic diseases
- History or symptoms of neurological diseases excluding specified stroke for patients
- Severe musculoskeletal issues affecting lower limbs or non-affected limbs for stroke patients
- Visual spatial perception disorders or hearing loss
- Color blindness
- Depression or psychiatric disorders
- Use of medications affecting the central nervous system
- Drug, substance, or alcohol addiction
- Participation in other brain stimulation research
- Deemed unsuitable for MRI or tDCS by a physician
- Affiliation with any research-conducting institution
AI-Screening
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Trial Site Locations
Total: 1 location
1
School and Graduate Institute of Physical Therapy, National Taiwan University
Taipei, Taiwan, 100
Actively Recruiting
Research Team
P
Pei-Fang Tang, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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