Actively Recruiting
Investigating the Effects of Transcranial Stimulation to Advance Stroke Rehabilitation
Led by University of Oxford · Updated on 2025-03-07
60
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Non-invasive brain stimulation (NIBS) has the potential to boost rehabilitation after stroke by creating a 'pro-plastic' environment, where the brain is more adaptable in response to movement (motor) training. However, responses to classical NIBS protocols are highly variable. Movement-related changes in specific brain rhythms have previously been shown to be related to recovery of hand/arm function after a stroke. The investigators propose to use NIBS to target movement-related activity in the beta band (13-30Hz) within the motor cortical regions of the brain. The investigators will use a type of NIBS called transcranial alternating current stimulation (tACS), which uses a sinusoidally-varying electrical current where the stimulation frequency is determined to be relevant to the underlying brain rhythms of interest, and the stimulation timed to coincide with specific phases of the hand/arm movement. The primary aim is to investigate whether beta-tACS improves upper limb movement in stroke survivors.
CONDITIONS
Official Title
Investigating the Effects of Transcranial Stimulation to Advance Stroke Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is willing and able to give informed consent for participation in the study.
- Aged 18 years or above.
- Clinical diagnosis of stroke affecting the upper limb, with sufficient ability to perform the upper limb reaching task.
- At least 3 months post-stroke and discharged from inpatient care.
You will not qualify if you...
- Inability to follow task instructions.
- Other neurological condition affecting movement (e.g. Parkinson's Disease, Multiple Sclerosis).
- Standard contraindications to non-invasive brain stimulation (TMS, tACS), including presence of intracranial metallic or magnetic hardware, seizures, pregnancy, pacemaker or other stimulators/implants.
- Insufficient verbal and written English to comprehend the study and provide informed consent.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Oxford Centre for Functional MRI of the Brain (FMRIB)
Oxford, United Kingdom, OX3 9DU
Actively Recruiting
Research Team
M
Melanie Fleming, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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