Actively Recruiting
Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
Led by Xuanwu Hospital, Beijing · Updated on 2025-06-27
20
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to collect detailed brain activity and clinical data from patients aged 14 to 65 who have drug-resistant epilepsy and have undergone stereoelectroencephalography (SEEG). The goal is to study how brain connectivity changes during wakefulness and sleep states, which is important because sleep affects brain function and neurological health. This study focuses on understanding brain network dynamics in a clinical population with epilepsy. Participants will undergo SEEG recordings combined with single-pulse electrical stimulation (SPES). SPES delivers low-frequency electrical pulses to the brain to map how different areas connect and communicate, while SEEG records brain activity with high precision. These procedures will be performed during both daytime and sleep over a 48-hour period to observe how brain networks change with vigilance states. During the study, participants will be monitored continuously with SEEG and SPES to gather electrophysiological data. Researchers will also measure hormone levels, including melatonin and various corticosteroids, dynamically over the same 48 hours. The primary outcome is to analyze SEEG recordings with SPES during wakefulness and sleep. Safety monitoring will exclude participants with surgical complications, and the total participation time covers the 48-hour recording and assessment period.
CONDITIONS
Brief Title
Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Drug-resistant focal epilepsy
- Justified SEEG exploration as part of presurgical epilepsy assessment
- Participation in epilepsy-monitoring unit for long-term SEEG recordings and analysis
- Written non-opposition to study participation
You will not qualify if you...
- Pregnant women (contraindication to SEEG exploration)
- Subjects with surgical complications during implant procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants are evaluated for suitability including epilepsy diagnosis and eligibility for SEEG exploration.
Duration - 48 hours
Participants undergo stereoelectroencephalography (SEEG) recordings combined with single-pulse electrical stimulation (SPES) to investigate brain connectivity and cortical excitability during wakefulness and sleep.
Continuous monitoring during approximately 48 hours in an epilepsy-monitoring unit
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Beijing
Beijing, Beijing Municipality, China, 100000
Actively Recruiting
Research Team
L
Liankun Ren, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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