Studying Brain Activity and Connectivity During Wakefulness and Sleep Using SEEG in People with Drug-Resistant Epilepsy

What this Trial Is About

This research aims to collect detailed brain activity and clinical data from patients aged 14 to 65 who have drug-resistant epilepsy and have undergone stereoelectroencephalography SEEG. The goal is to study how brain connectivity changes during wakefulness and sleep states, which is important because sleep affects brain function and neurological health. This study focuses on understanding brain network dynamics in a clinical population with epilepsy. Participants will undergo SEEG recordings combined with single-pulse electrical stimulation SPES. SPES delivers low-frequency electrical pulses to the brain to map how different areas connect and communicate, while SEEG records brain activity with high precision. These procedures will be performed during both daytime and sleep over a 48-hour period to observe how brain networks change with vigilance states. During the study, participants will be monitored continuously with SEEG and SPES to gather electrophysiological data. Researchers will also measure hormone levels, including melatonin and various corticosteroids, dynamically over the same 48 hours. The primary outcome is to analyze SEEG recordings with SPES during wakefulness and sleep. Safety monitoring will exclude participants with surgical complications, and the total participation time covers the 48-hour recording and assessment period.

Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG