Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
NCT06086873

Investigating Implant Surface Effect on Osseointegration: NGA vs. ModSLA

Led by Barts & The London NHS Trust · Updated on 2026-04-22

39

Participants Needed

1

Research Sites

186 weeks

Total Duration

On this page

Sponsors

B

Barts & The London NHS Trust

Lead Sponsor

V

Virginia Commonwealth University

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study aims to characterise the stability of crestal bone levels one year after loading, the associated aesthetic outcomes, immunological response, prosthodontic outcomes as well as overall patient reported outcome measures for modSLA (SLActive, Institut Straumann AG, Switzerland) and NGA (TiUltraNP, Nobel Biocare AG, Switzerland) dental implants.

CONDITIONS

Official Title

Investigating Implant Surface Effect on Osseointegration: NGA vs. ModSLA

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age over 18 years old
  • Male and female gender
  • Ability and willingness to follow study procedures and provide informed consent
  • Require tooth extraction of a maxillary first premolar or single-rooted anterior tooth due to caries, endodontic failure, or trauma
  • Extraction site must have adjacent teeth present
  • Adjacent teeth must show no evidence of interdental bone loss
Not Eligible

You will not qualify if you...

  • Systemic diseases interfering with dental implant therapy (e.g., uncontrolled diabetes)
  • Two adjacent teeth requiring extraction
  • More than one wall of the socket missing at extraction
  • Contraindications for oral surgical procedures
  • Systemic diseases affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis, type I and uncontrolled type II diabetes), systemic infections, or recent surgery within 30 days before study start
  • Chronic use (2 weeks or more) of medications affecting oral status or bone metabolism within 1 month before baseline
  • HIV or viral hepatitis infection
  • Physical handicaps affecting oral hygiene ability
  • History of local irradiation in head-neck region
  • Mucosal diseases (e.g., erosive lichen planus)
  • Current untreated periodontitis or gingivitis, especially probing depths >4mm on teeth adjacent to extraction site
  • Untreated acute endodontic lesions
  • Current smokers or smoked within 3 months before study
  • Alcoholism or chronic drug abuse
  • Psychological disorders or limited mental capacity/language skills preventing understanding of study information
  • Non-compliance or inability to give informed consent
  • Pregnant or breastfeeding
  • Current or recent participation in other research
  • Full-mouth bleeding and plaque scores >30% or periodontal pockets >5 mm after pre-treatment phase

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Royal London Dental Institute

London, United Kingdom, E1 1BB

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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