Actively Recruiting
Investigating the Insulin Resistance in Individuals With Type 2 Diabetes
Led by Central South University · Updated on 2024-09-19
30
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Numerous studies have provided evidence of a correlation between Type 2 Diabetes Mellitus (T2DM) and cognitive dysfunction, specifically in the realms of complex attention, information processing, and executive function. These impairments have been observed in middle-aged and elderly individuals with T2DM, with longer diabetes duration, suboptimal glycemic control, and the presence of diabetic complications being contributing factors. Recent research in young adults and adolescents diagnosed with T2DM has revealed cognitive and brain structural alterations in this growing demographic, suggesting that early disease mechanisms, rather than solely vascular and age-related neurodegeneration, contribute to pathogenesis. However, there remains uncertainty regarding the interplay between central and peripheral insulin resistance and its impact on cognitive dysfunction in individuals with T2DM. This study aims to investigate central insulin resistance in T2DM, elucidating its association with peripheral insulin resistance and the effects on cognitive impairments.
CONDITIONS
Official Title
Investigating the Insulin Resistance in Individuals With Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Type 2 diabetes based on standard criteria including symptoms plus blood glucose or HbA1c levels
- Confirmation by re-examination if no typical diabetes symptoms are present
You will not qualify if you...
- History of substance dependence or abuse or symptoms caused by diagnosable mental disorders
- History of traumatic brain injury, seizures, or other known neurological or central nervous system diseases
- Current suicidal or homicidal thoughts or safety concerns not manageable in inpatient care
- Use of drugs affecting cognitive function
- Significant abnormal renal or liver function or other serious somatic diseases based on routine blood tests
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
Research Team
J
Jing Huang, MD
CONTACT
J
Jingmei Xiao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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