Actively Recruiting
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Led by Douglas Mental Health University Institute · Updated on 2024-05-03
134
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis abstinence in people with psychosis and non-psychiatric controls with cannabis use. Participants will be randomized to a cannabis abstinent group or a non-abstinent control group and will undergo magnetic resonance imaging at baseline and following 28-days of abstinence. This study will help characterize the neuropathophysiological processes underlying cognitive dysfunction associated with cannabis use and its recovery which may guide the development of novel interventions for problematic cannabis use.
CONDITIONS
Official Title
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent in English or French
- Heavy cannabis use (weekly use for at least six months) and/or DSM-5 diagnosis of cannabis use disorder
- Full-Scale IQ of 75 or higher
- Meet DSM-5 criteria for a psychotic disorder (for psychosis patients only)
- Outpatient on stable medication doses for at least two months (for psychosis patients only)
- Clinically stable with PANSS-6 total score less than 30 (for psychosis patients only)
You will not qualify if you...
- Current substance use disorder other than cannabis use disorder
- Contraindications for MRI
- Positive urine test for substances other than cannabis, nicotine, or caffeine
- Current suicidal or homicidal thoughts
- Past head injury requiring hospitalization or loss of consciousness longer than 5 minutes
- Medical diseases requiring hospitalization or regular monitoring
- Pregnancy
- DSM-5 Axis 1 diagnosis other than cannabis use disorder (for non-psychiatric controls only)
- Use of psychotropic medication
AI-Screening
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Trial Site Locations
Total: 1 location
1
Douglas Mental Health University Institute
Montreal, Quebec, Canada, H4H 1R3
Actively Recruiting
Research Team
C
Charlene Osei-Afrifa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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