Study of ATP Production in Airway Epithelium Among Adults with Difficult-to-Treat or Unexplained Chronic Cough Compared to Healthy Adults

What this Trial Is About

Researchers are investigating the role of ATP production by the airway epithelium in patients with refractory and unexplained chronic cough RCCUCC, a condition affecting about 10% of people globally with varying severity. The study aims to find if the airway epithelium produces more ATP in RCCUCC patients compared to healthy individuals and whether gene and protein expressions linked to ATP production differ between these groups. It also explores if ATP release is triggered by mechanical or chemical stimulation and if gene expression patterns can distinguish RCCUCC patients from healthy controls. The study involves performing bronchoscopy, a diagnostic test, on both RCCUCC patients and healthy controls to collect airway samples for analysis. This observational study compares gene expression, immune cell levels, cytokines, nerve morphology, and ATP release over time between these two groups. The primary outcome is the difference in expressed genes at baseline, with secondary outcomes including changes in immune cells and cytokines at 12 months and ATP release at several time points. Participants will undergo assessments including spirometry to measure lung function and bronchoscopy to collect samples. Researchers will analyze gene expression, nerve structure, and immune responses. The study tracks cough severity and airflow measures at screening and monitors participants for up to 12 months to observe changes. Safety evaluations include screening for recent infections and smoking history. The total involvement duration varies but includes baseline and follow-up assessments to understand the biological differences associated with chronic cough.

Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).