Actively Recruiting
Investigating Serotonin Signalling in IBD Patients
Led by McMaster University · Updated on 2024-11-20
60
Participants Needed
1
Research Sites
721 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in enterochromaffin (EC) cell, main source of 5-HT in the gut, numbers in CD and UC patients. Up-regulated expression of mucosal Tryptophan hydroxylase (TPH)-1, catalytic enzyme in 5-HT production, messenger RNA (mRNA) have been found in CD patients in remission who are suffering the irritable bowel syndrome (IBS)-like symptoms. Alterations in normal 5-HT signaling has also been reported in animal models of inflammatory bowel disease (IBD). Thus, the aim of the proposed research project will be to study the alterations in 5-HT signalling accompanying GI inflammatory conditions, such as IBD.
CONDITIONS
Official Title
Investigating Serotonin Signalling in IBD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with Crohn's disease or ulcerative colitis
- Details of disease duration, previous and current treatments, and disease prognosis must be available
- Healthy controls must have no diagnosis of Crohn's disease, ulcerative colitis, or irritable bowel syndrome
You will not qualify if you...
- Use of drugs that directly affect serotonin (5-HT) signaling
- Presence of any other disease or condition that may interfere with study assessments as judged by the investigator
- Chronic use of any anti-inflammatory drugs for healthy controls
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
McMaster University Medical Center
Hamilton, Ontario, Canada, L8S 4K1
Actively Recruiting
Research Team
J
Jensine Grondin, MSc.
CONTACT
T
Tyler Seto, BSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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