Actively Recruiting
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Led by Zuyderland Medisch Centrum · Updated on 2026-04-13
556
Participants Needed
2
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial) burden on the health care system. Treatment often consists of the administration of IV decongestive agents. Adequate dosing is difficult due to varying diuretic resistance and inadequate parameters to evaluate the response. Urine sodium is a promising biomarker to evaluate the diuretic response. It is hypothesized that a tailored, urine sodium guided diuretic algorithm will result in faster and more complete decongestion and therefore lead to better survival (in terms of mortality and heart failure events) while being non-inferior in terms of safety (mainly regression of kidney function).
CONDITIONS
Official Title
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Diagnosis of heart failure (HFrEF, HFmrEF, or HFpEF) based on 2021 European Society of Cardiology guidelines
- Presentation with acute heart failure including at least one symptom (dyspnea, orthopnea, or edema) and one sign (rales, peripheral edema, ascites, or pulmonary vascular congestion on chest radiography)
- Elevated NT-proBNP level over 300 pg/ml
- Need for intravenous diuretic treatment
You will not qualify if you...
- Terminal renal insufficiency (dialysis or eGFR < 10 mL/min/1.73 m2)
- Participation in other investigational heart failure studies
- Presence of cardiogenic shock, respiratory insufficiency, or admission to intensive care unit at arrival (later ICU transfer during hospitalization allowed)
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Zuyderland MC
Heerlen, Limburg, Netherlands, 6419 PC
Actively Recruiting
2
Amphia ziekenhuis
Breda, North Brabant, Netherlands, 4818 CK
Actively Recruiting
Research Team
S
Sandra van Wijk, MD, PhD
CONTACT
M
Mick Hoen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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