Actively Recruiting
Investigating the Tumour Immune Response of Radiotherapy
Led by University of Manchester · Updated on 2025-06-11
120
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
Sponsors
U
University of Manchester
Lead Sponsor
T
The Christie NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate immune changes which occur before and following standard radiotherapy in a range of tumour types. We will collect tissue and blood samples before and after radiation treatment from participants across six cancer types: cervical, rectal, Head and Neck cancer, nodal non-Hodgkin lymphoma, cutaneous lymphoma and cutaneous squamous cell carcinoma/ basal cell carcinoma.
CONDITIONS
Official Title
Investigating the Tumour Immune Response of Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed cancer, Stage I-IV, in one of the following: Cervical, rectal, nodal Non-Hodgkin lymphoma, cutaneous lymphoma, Head & neck cancer
- Diagnostic or pre-treatment biopsy confirmed suitable for translational research
- Performance status ECOG 0-2 (ECOG 3 allowed for arm F unrelated to cancer)
- Age 18 years or older, no upper age limit
- Participant considered suitable for radiotherapy
- Written informed consent given according to GCP and national regulations
- Pre-treatment biopsy from gross tumour volume within planned radiation field, formalin fixed >12h and <72h, tumour tissue confirmed by H&E staining, and contains approximately 100 tumour cells
You will not qualify if you...
- Unsuitable for biopsy during or after radiotherapy as judged by treating oncologist
- Received chemotherapy within 28 days before starting radiotherapy
- Known history or current infection with hepatitis B, hepatitis C, or HIV (negative test required before inclusion)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
L
Lois Gardner
CONTACT
E
Eleanor Cheadle
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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