Combining tDCS with prismatic adaptation for non-invasive neuromodulation of the motor cortex.
Martina Bracco, Giuseppa Renata Mangano, Patrizia Turriziani...
https://pubmed.ncbi.nlm.nih.gov/28487249Actively Recruiting
Phase Not Applicable
Age: 20Years - 85Years
All Genders
ID06640660
Investigating Visuo-spatial Abilities and Psychological Effects in West Nile and Multiple Sclerosis Patients with a Focus on a Possible Rehabilitation Protocol
Led by IRCCS San Camillo, Venezia, Italy · Updated on 2024-10-15
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying visuospatial abilities and psychological outcomes in patients with Multiple Sclerosis (MS) and West Nile virus infection (vWN). Both conditions can affect cognitive functions such as attention, memory, and executive skills. This study aims to better understand these impairments and test a new rehabilitation approach to improve visuospatial and cognitive functions. Participants will receive 10 sessions over 2 weeks of cognitive training using Mindlenses Professional, a device that combines prismatic adaptation therapy with digital serious games targeting attention, executive functions, and language. There is also a comparison group receiving standard computerized cognitive rehabilitation offered by the hospital. During the study, patients will undergo neuropsychological and psychological evaluations before and after the treatment to assess changes in cognitive performance and psychological status. The primary outcome measures cognitive changes after the 2-week intervention, while secondary outcomes assess psychological effects. The study involves randomized assignment and single masking, with a total participation period of about 2 weeks.
CONDITIONS
Brief Title
Investigating Visuo-spatial Abilities and Psychological Effects in West Nile and Multiple Sclerosis Patients with a Focus on a Possible Rehabilitation Protocol
Who Can Participate
Age: 20Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosis of Multiple Sclerosis or West Nile virus infection confirmed by lab tests within 12 months before hospitalization
- Use of at least one hand is preserved
- Normal or corrected-to-normal vision
You will not qualify if you...
- History of psychiatric or other neurological diseases
- Unable to provide informed consent
- Difficulty understanding spoken instructions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 2 weeks
Participants undergo 2 weeks of cognitive rehabilitation. The experimental group uses Mindlenses Professional combining prismatic adaptation and serious games focused on attention, executive functions, and language. The control group performs standard cognitive training.
10 sessions over 2 weeks
Follow-up
Duration - Immediately after treatment (post-intervention)
Participants are assessed for changes in cognitive performance and psychological aspects after the treatment.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
IRCCS San Camillo Hospital
Lido, Venezia, Italy, 30126
Actively Recruiting
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Long-term clinical and neuropsychological outcomes of West Nile virus infection.
Paul J Carson, Patrick Konewko, Kimberly S Wold...
https://pubmed.ncbi.nlm.nih.gov/16912946Treating learning impairments improves memory performance in multiple sclerosis: a randomized clinical trial.
Nancy D Chiaravalloti, John DeLuca, Nancy B Moore...
https://pubmed.ncbi.nlm.nih.gov/15732268Cognitive impairment in multiple sclerosis.
Nancy D Chiaravalloti, John DeLuca
https://pubmed.ncbi.nlm.nih.gov/19007738Virology, pathology, and clinical manifestations of West Nile virus disease.
Edward B Hayes, James J Sejvar, Sherif R Zaki...
https://pubmed.ncbi.nlm.nih.gov/16102303Prismatic adaptation as a novel tool to directionally modulate motor cortex excitability: evidence from paired-pulse TMS.
Barbara Magnani, Carlo Caltagirone, Massimiliano Oliveri
https://pubmed.ncbi.nlm.nih.gov/24934876Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders.
Laure Pisella, Gilles Rode, Alessandro Farnè...
https://pubmed.ncbi.nlm.nih.gov/17102690Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction.
S M Rao, G J Leo, L Bernardin...
https://pubmed.ncbi.nlm.nih.gov/2027484