Actively Recruiting
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
Led by University of North Carolina, Chapel Hill · Updated on 2025-03-30
40
Participants Needed
2
Research Sites
285 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.
CONDITIONS
Official Title
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-45 years
- HbA1C <6.5%
- Normal weight individuals: BMI 17-25 kg/m^2
- Obese individuals: BMI >30 kg/m^2
You will not qualify if you...
- Creatinine >1.5mg/dL
- Hematocrit <35% for females and <39% for males
- ALT and AST >2.5X upper limit of normal
- Abnormal TSH
- Abnormal PT/PTT/INR
- Triglycerides >200 mg/dL
- Known hepatic, gastrointestinal, renal, neurologic, psychiatric, cerebrovascular disease
- Uncontrolled hypertension
- Current or past 3 months use of ketogenic diet
- Use of any medications, vitamins, or supplements that can alter cerebral metabolism or lipids
- Smoking
- Current or recent steroid use in last 6 months
-
5% body weight change in last 6 months
- Illicit drug use/alcoholism
- Inability to enter MRI/MRS
- For women: pregnancy, seeking pregnancy, or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Biomedical Research Imaging Center Marsico Hall (UNC)
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
2
Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC)
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
Research Team
J
Joseph Palmiotto
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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