Study of Antimicrobial Temporary Push-On Rings for Dental Implant Abutments to Compare Biofilm Formation Over Time

What this Trial Is About

This research investigates the formation and composition of bacterial biofilm on temporary push-on rings made from noble-alloy-based material Pagalinor PA compared to Titanium-6Aluminum-7Niobium alloy TAN, commonly used in dental implant abutments. The study focuses on early 48 hours, mature 2 weeks, and long-term 3 months biofilm development to understand its role in peri-implantitis and tissue response. It is a randomized clinical study assessing antibacterial potential of these materials in the natural oral implant environment. Participants will wear both test and control rings, either simultaneously on two implants split-mouth design or consecutively if only one implant is present, allowing within-subject comparison. Rings are pushed onto the titanium base of implant crowns and replaced after 48 hours, 2 weeks, and 3 months for biofilm sampling. The study period is 4 months for those with two implants and 8 months for those with one implant. During the study, researchers will collect samples to measure total bacterial load and analyze bacterial diversity using metagenomic sequencing. Clinical assessments include probing pocket depth, bleeding on probing, laser doppler flowmetry, and peri-implant soft tissue cell changes. These evaluations occur at baseline and follow-up points to monitor biofilm and tissue response, supporting understanding of long-term implant health. Participants involvement includes wearing the rings and attending scheduled visits for sample collection and assessments.

Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns