Temporary push-on Rings of Antimicrobial Alloys for Transmucosal Implant Abutment Systems: a Randomized Clinical Study on Early and Mature Biofilm Formation

What this Trial Is About

This research aims to study how biofilms form and change over time on temporary push-on rings made from different materials used in dental implant abutments. The study compares a noble-alloy-based material called Pagalinor (PA) to the commonly used Titanium-6Aluminum-7Niobium alloy (TAN) in patients with titanium bone level implants. Understanding biofilm formation on these materials may help reduce bacterial-related peri-implant diseases like peri-implantitis. Participants will wear temporary push-on rings made from either the PA test material or the TAN control material, which are placed on the conical titanium base of their implant crowns. The rings, 0.2mm thick, will be replaced after 48 hours, 2 weeks, and 3 months to measure bacterial biofilm. In patients with two implants, the rings will be applied simultaneously in a split-mouth design; in patients with one implant, the rings will be used consecutively. The study duration is 4 months for split-mouth and 8 months for single implant participants. Throughout the study, researchers will collect and analyze biofilm samples from the rings to measure total bacterial load and changes in bacterial composition over time. They will also assess clinical measures such as probing pocket depth, bleeding on probing, laser doppler flowmetry, and peri-implant soft tissue cells at specified time points. These assessments will provide insight into biofilm development and tissue response with each material over the short and long term.

Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns