Study of Brain Tumor Metabolism Using 13C-Glucose Infusion and Surgical Tumor Removal with Advanced Imaging and Molecular Analysis

What this Trial Is About

Researchers are studying patients with a newly found brain mass to understand the tumors metabolic characteristics by using a non-radioactive glucose isotope infusion during surgical removal. The study aims to link these metabolic profiles with tumor tissue analysis and imaging results, seeking to identify active tumor cells and compare metabolic data with molecular and histological features. Patients will be monitored over time to study treatment responses and tumor progression. Participants will receive an infusion of a labeled glucose solution before and during their brain tumor surgery. Before surgery, patients undergo advanced brain imaging, including PET scans and specialized MRI scans, some for research purposes only. During surgery, tumor tissue samples are collected for detailed metabolic and molecular analyses. After surgery, patients have follow-up visits and ongoing contact every six months for up to five years to gather treatment and outcome data. Throughout the study, patients will have blood samples taken during glucose infusion and be assessed for side effects shortly after surgery. Researchers will collect and analyze imaging data, molecular profiles, and clinical outcomes like tumor progression and survival. The total follow-up period can last several years, with regular check-ins to understand the tumors behavior and treatment effects better.

An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection