Actively Recruiting
Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women
Led by Queen Mary University of London · Updated on 2026-01-07
34
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood. It is likely that key differences in the underlying biological mechanism, in particular in inflammatory responses, play a part in underpinning these differences. Previous evidence demonstrates that healthy females appear to be more adept at resolving inflammation compared to healthy males. Since inflammation is thought to be a key initiating phenomenon in coronary artery disease the investigators will examine the differences in inflammatory resolution between the sexes in healthy volunteers.
CONDITIONS
Official Title
Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy male and female volunteers
- Aged 18-45
- Volunteers who are willing to sign the consent form
You will not qualify if you...
- Healthy subjects unwilling to consent
- Pregnant or possibly pregnant unless a negative pregnancy test is confirmed
- Currently breastfeeding
- History of serious illnesses, recent infections, or trauma
- Taking systemic medication other than oral contraceptive pills
- Recent (within 2 weeks) or current antibiotic use
- History of blood-borne infectious diseases such as Hepatitis B, Hepatitis C, or HIV
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The William Harvey Research Institute
London, United Kingdom, EC1M 6BQ
Actively Recruiting
Research Team
A
Amrita Ahluwalia, BSc PhD
CONTACT
A
Andrew J Sullivan, MBBS BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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