Study of Lipikar Baume APM Effects on Skin Barrier and Microbial Changes in Adults With Actinic Keratoses on Forearms and Hands

What this Trial Is About

Researchers are studying adults with actinic keratoses AK lesions on their forearms and backs of hands to observe how Lipikar Baume APM affects skin barrier function, water loss through the skin, and changes in skin microbes. This is a randomized, evaluator-blinded study conducted in Germany, enrolling 20 adult participants with grade I to III AK lesions and similar severity on both arms. Participants will apply Lipikar Baume APM at least twice daily for 4 weeks on one randomly selected arm, while the other arm receives no intervention. The study includes a total of two visits a screeningbaseline visit at the start Day 0 and a final visit at the end of the 4-week application period Day 28. During participation, researchers will measure skin hydration, transepidermal water loss, and the severity and area of AK lesions using the AKASI score. They will also evaluate colonization by specific skin bacteria and assess skin appearance. Additional assessments include lesion counts, symptom severity, treatment satisfaction, and compliance with the application schedule. Photographs will be taken at all time points to monitor changes. The total study duration for each participant is 4 weeks.

Investigation of the Effect of Lipikar Baume AP+M