Actively Recruiting
Investigation of the Effectiveness of Exercise and Anti-Fibrotic Approaches in Frozen Shoulder
Led by Istanbul University · Updated on 2026-04-07
33
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical study is to investigate the efficacy of losartan as an antifibrotic approach in addition to a physiotherapy program in patients diagnosed with frozen shoulder. The effects of losartan use on pain intensity, shoulder joint range of motion, functional status, and pain catastrophizing level will be evaluated and compared with the outcomes of patients participating in a physiotherapy program alone. The key questions this study aims to answer are: * Is there a difference in shoulder functionality between frozen shoulder patients using losartan in addition to a physiotherapy program and those participating in a physiotherapy program alone? * Is there a difference in pain intensity, shoulder joint range of motion, and pain catastrophizing level between frozen shoulder patients using losartan in addition to a physiotherapy program and those participating in a physiotherapy program alone? A total of 33 patients will be enrolled in the study. Participants will be randomly assigned to one of two groups: the physiotherapy group (PT) and the physiotherapy + losartan group (PT+L). Both groups will receive the same physiotherapy program comprising range of motion exercises, stretching exercises, strengthening exercises, and mobilization techniques. Patients in the PT+L group will additionally receive 12.5 mg of oral losartan once daily for four weeks. Clinical assessments will be conducted at baseline, at week 4, and at week 8.
CONDITIONS
Official Title
Investigation of the Effectiveness of Exercise and Anti-Fibrotic Approaches in Frozen Shoulder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older diagnosed with frozen shoulder (adhesive capsulitis)
- Less than 50% range of motion in at least one shoulder movement compared to the unaffected side
- More than 25% loss of range of motion in at least two shoulder movement planes compared to the unaffected shoulder
- Patients in stage II or III of frozen shoulder
You will not qualify if you...
- Women who are pregnant, breastfeeding, or planning pregnancy during the study
- Patients in stage I of frozen shoulder
- Patients with inflammatory or autoimmune arthritis affecting the shoulder
- Patients with rotator cuff pathology and/or glenohumeral arthritis
- Patients with prior shoulder infection
- Patients with low blood pressure (hypotension)
- Patients who had or plan to have upper extremity surgery during the study
- Patients allergic to losartan or its components
- Patients taking medications that interact adversely with losartan
- Patients with any medical condition or history that may risk safety or affect study participation as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Istanbul University-Cerrahpasa
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
A
Ayşe Betül Erol, Bachelor's degree
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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