Actively Recruiting

Age: 18Years - 40Years
FEMALE
Healthy Volunteers
NCT06470958

Investigation of Functional Brain Features in Women with Migraine

Led by Danish Headache Center · Updated on 2024-11-04

40

Participants Needed

1

Research Sites

94 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study aims to investigate whether the functional alterations in the brain of individuals with migraine appear before the peripheral vascular changes. This will be investigated using functional and structural neuroimaging in individuals with spontaneous menstually-related migraine.

CONDITIONS

Official Title

Investigation of Functional Brain Features in Women with Migraine

Who Can Participate

Age: 18Years - 40Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Women aged 18 to 40 years
  • Weight between 50 and 100 kg
  • Regular menstruation
  • For migraine group: Episodic menstrually-related migraine without aura for more than 12 months according to ICHD-3 criteria
  • For healthy women: No history of primary headaches except infrequent episodic tension-type headache
  • Use of safe contraception if fertile
Not Eligible

You will not qualify if you...

  • Other primary headache disorders besides migraine except infrequent episodic tension-type headache
  • Secondary headache disorders
  • Headache on the first scan day or within 48 hours before the first scan
  • No menstruation for the past 12 months
  • Daily use of medications except oral contraceptives
  • Medication taken later than four times the plasma half-life on scan day except oral contraceptives
  • Intake of coffee, tea, or alcohol within 12 hours prior to scan days
  • Fertile women not using safe contraception
  • Change of hormonal contraceptives within the past 3 months
  • Perimenstrual syndrome
  • Pregnancy or breastfeeding
  • Hypertension (systolic >150 mm Hg or diastolic >100 mm Hg)
  • Low blood pressure (systolic <100 mm Hg or diastolic <50 mm Hg)
  • Cardiovascular diseases including cerebrovascular disease
  • Diabetes
  • Unregulated mental illness or substance abuse
  • Any illness deemed incompatible by the examining physician
  • Contraindications to MRI including metal in the body or claustrophobia
  • Unwillingness to be informed about unexpected pathological MRI findings

AI-Screening

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Trial Site Locations

Total: 1 location

1

Danish Headache Center

Glostrup Municipality, Denmark

Actively Recruiting

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Research Team

F

Faisal Mohammad Amin

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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