Actively Recruiting
Investigation of the Influence of the Human Microbiome on Giant Cell Arteritis
Led by University of Bonn · Updated on 2024-05-09
50
Participants Needed
2
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The longitudinal observational study aims to assess the impact of the microbiome especially the gut-microbiome in the emergence and course of giant cell arteritis (abbr. GCA) patients. At diagnosis and 6 month follow up we will analyze the oral, blood and gut microbiome from GCA patients and healthy controls. Thereby identified potential candidate biota will be further analyzed for possible interactions and influence on the immune system.
CONDITIONS
Official Title
Investigation of the Influence of the Human Microbiome on Giant Cell Arteritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Giant cell arteritis (only in one arm)
You will not qualify if you...
- Chronic infection including HIV, Hepatitis B, or Hepatitis C
- Acute infection with antibiotic use less than 90 days before screening
- Major gastrointestinal surgery within 5 years before screening
- Gastrointestinal bleeding within 90 days before screening
- Confirmed inflammatory bowel disease
- Bulimia or anorexia nervosa
- Body mass index of 40 or higher
- Use of high-dose probiotics (more than 10^9 colony forming units per day) within 90 days before screening
- Uncontrolled diabetes mellitus
- Malignancy within one year except certain skin cancers and cervix carcinoma with curative surgery
- Known alcohol or drug abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
2
University Hospital Bonn
Bonn, Germany, 53127
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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