Study of How Kidney and Urothelial Cancers Use Different Nutrients During Surgery or Biopsy

What this Trial Is About

Researchers are investigating how kidney cancers, including renal cell carcinomas and urothelial cell carcinomas, use different nutrients to support tumor growth. The study aims to understand how these cancers metabolize various nutrients found in the blood and common foods. This knowledge may help develop new treatments targeting cancer metabolism and improve imaging techniques for kidney cancer care. Participants may receive an intravenous infusion of a specially labeled nutrient tracer, such as 13C-glucose, 13C-acetate, 13C-lactate, 13C-glutamine, or 13C-fructose, during surgery or biopsy. The infusion typically lasts 2 to 3 hours before tumor removal. Blood samples will be collected every 30 minutes during the infusion to monitor safety and track nutrient use by the tumor. Some participants will have tissue collected without infusion after surgery or biopsy. During the study, participants will undergo standard surgical procedures for their cancer without changes to their usual care. Researchers will collect tissue samples during or after surgery or biopsy to analyze how cancer cells use the infused nutrients. Blood tests will be done regularly during infusion to monitor glucose levels and blood acidity. The main outcome measured is the distribution of the labeled nutrient in the cancer tissue over five years. Participation duration varies depending on surgery timing and follow-up needs.

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy