Actively Recruiting
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy
Led by University of Texas Southwestern Medical Center · Updated on 2026-01-28
600
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
H
Howard Hughes Medical Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different types of fuel to support tumor growth. This study uses specially labeled nutrient tracers of compounds normally found circulating in the blood. The nutrients (glucose, fructose, glutamine, acetate, and lactate) are also found in common foods. A nutrient tracer will be given to the participants through an intravenous (IV) catheter during surgery or biopsy, and blood will be collected every 30 minutes during the infusion to monitor safety parameters and the nutrient tracers. The investigators will collect a tissue sample after the completion of surgery. Participants not having an infusion will have their tissue collected after surgery or biopsy. Participation in this study will not change patient care. All patients will receive standard of care treatment as determined by their doctors.
CONDITIONS
Official Title
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must have radiographic evidence of known or probable kidney or urothelial cancer requiring surgical biopsy or excision.
- Age 18 years or older
- Subjects of all races and ethnic origins
- Willingness and ability to sign a written informed consent
- Patients in other clinical trials may be eligible and will be evaluated individually by the Principal Investigator
You will not qualify if you...
- Uncontrolled or poorly controlled diabetes for patients receiving a 13C infusion
- Pregnant or breastfeeding
- Not a surgical candidate
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
V
Vitaly Margulis, MD
CONTACT
R
Ralph J DeBerardinis, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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