Actively Recruiting
Investigation of Locus Coeruleus Function in Sustained Attention
Led by University of California, Davis · Updated on 2025-12-12
40
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop methods that permit measurement of activity in the human LC. Because the LC is small and located in the pons, the Investigators will use high resolution magnetic resonance imaging techniques tailored to the brainstem environment, including neuromelanin-sensitive images shown to delineate the LC, combined with pharmacological manipulation to confirm the location of functional activity.
CONDITIONS
Official Title
Investigation of Locus Coeruleus Function in Sustained Attention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between the ages of 18 - 60 years of age
- Typically developing, healthy adult
You will not qualify if you...
- History of schizophrenia, other forms of psychosis
- Specific or focal neurological disorder or severe alcohol or drug use disorder within the past 5 years
- History of left ventricular hypertrophy or mitral valve prolapse syndrome related to CNS stimulants, or recent myocardial infarction or unstable angina
- Known hypersensitivity or allergy to modafinil, armodafinil, or their inactive ingredients
- Inability to swallow tablets or tolerate oral medication
- Pregnant or nursing (negative pregnancy test required)
- Contraindications for MRI scanning such as metal implants, pacemakers, metal foreign bodies, or pregnancy
- Use of psychotropic medication within the past week
- Claustrophobia or discomfort with small spaces
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California, Davis
Sacramento, California, United States, 95817
Actively Recruiting
Research Team
J
Julie Schweitzer, PhD
CONTACT
J
Jared Borden, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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