Actively Recruiting

Age: 18Years - 65Years
FEMALE
Healthy Volunteers
ID07294014

Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema: A Cross-Sectional Study

Led by Marmara University · Updated on 2026-01-02

32

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to explore the relationship between lipedema, a chronic disorder causing disproportionate fat buildup mainly in the lower limbs, and foot structure and function. It focuses on whether women with lipedema have more joint laxity, hypermobility, and foot abnormalities such as flat feet (pes planus) compared to women without lipedema but with similar age and body mass index. The study uses detailed radiographic and clinical assessments to understand these biomechanical changes and their impact on foot posture and function. Women diagnosed with lipedema and matched control participants with nonspecific foot pain will be assessed in a single session. Both groups will undergo standardized lateral foot X-rays to measure angles that indicate foot arch and alignment. Clinical tools like the Beighton score will measure joint hypermobility, and validated questionnaires will evaluate foot function, pain, and physical activity. All assessments are done once to compare foot structure and function between the groups. Participants will provide demographic and clinical information, including disease duration and comorbidities. The study collects radiographic data, joint mobility scores, and responses to foot function and pain questionnaires. Researchers will analyze this data to identify links between lipedema, joint hypermobility, and foot abnormalities. The primary measures are the foot angles from X-rays, with additional clinical and functional outcomes recorded. The study duration for participants is a single visit.

CONDITIONS

Brief Title

Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema

Who Can Participate

Age: 18Years - 65Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Female participants
  • Age 18 years or older and up to 65 years
  • Able to read and write
  • Availability of bilateral lateral foot radiographs within the past year
  • Willing and able to provide written and verbal informed consent
  • Clinical diagnosis of lipedema for the lipedema group
  • Female patients with nonspecific foot pain and no lipedema for the control group
  • Similar age and BMI range for control group compared to lipedema group
Not Eligible

You will not qualify if you...

  • Pregnancy
  • Illiteracy
  • Inability or unwillingness to provide written and verbal informed consent
  • History of lower extremity fracture, trauma, or orthopedic surgery
  • Diagnosis of diabetes mellitus
  • Known rheumatologic disease
  • Known polyneuropathy or peripheral nerve injury affecting the lower extremities

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - 1 day

Participants undergo radiographic foot assessments, joint hypermobility evaluation, and functional testing during a single study visit.

1 visit (in-person)

Trial Site Locations

Total: 1 location

1

Marmara University Pendik Training and Research Hospital

Istanbul, Turkey (Türkiye)

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Research Team

G

Gökçenur Yalçın, M.D., PMR Specialist

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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