Actively Recruiting
Investigation of Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders
Led by University Hospital, Strasbourg, France · Updated on 2025-08-03
84
Participants Needed
1
Research Sites
413 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The current diagnostic criteria for schizophrenia and other psychotic disorders are relatively broad and lack precision. Therefore, distinct diseases may be grouped together under the same diagnostic category, although these diseases may differ according to their clinical expression, prognosis and perhaps their physiopathological causes. We think that identifying subforms of psychotic disorders that are more homogeneous will better enable to understand their respective physiopathological causes and find personalized treatments. This study will compare two subforms of psychotic disorders that have been clinically distinguished in the 1970s. These phenotypes have however not been validated yet using scientific investigations. Using clinical assessments, cognitive evaluations and neurophysiological measures (fMRI) investigating the domains of affect and psychomotoricity , we expect that these two subforms will differ on their clinical, cognitive and neurophysiological characteristics, namely: hebephrenia will be associated with deficits on the affect markers , and respect psychomotoricity (catatonia scales, tests assessing movement planification) whereas the opposite pattern will be observed for periodic catatonia.
CONDITIONS
Official Title
Investigation of Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female willing to participate and who have signed the legal document
- Covered by health insurance (patients only)
- Diagnosed with schizophrenia or schizo-affective disorder according to DSM-5 criteria
- Diagnosed with periodic catatonia or hebephrenia according to WKL classification
- Clinically stable for at least 2 months
- Inpatient or outpatient status (controls only)
- No psychiatric history (controls only)
You will not qualify if you...
- Current severe or unstable physical illness
- History of neurological conditions such as epilepsy, brain injury, or brain surgery
- Current substance use disorder according to DSM-5
- Current major depressive disorder according to DSM-5
- Mental retardation with IQ below 70
- Pregnancy or breastfeeding
- Under current legal control
- Contraindication for fMRI (controls only)
- Psychotropic medication use within the last 3 weeks (controls only)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Service de Psychiatrie I, Hôpital Civil, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091
Actively Recruiting
Research Team
F
Fabrice BERNA, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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