Actively Recruiting
Investigation of Protein Differences in Extracellular Vesicles from Various Blood Regions in Patients with Ruptured or Unruptured Intracranial Aneurysms
Led by The First Hospital of Jilin University · Updated on 2026-02-27
120
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying protein differences in extracellular vesicles (EVs) found in blood from various parts of the body in patients with ruptured or unruptured intracranial aneurysms. The study aims to understand how EV proteins vary between different blood vessels and to find protein markers that may help diagnose and predict outcomes in subarachnoid hemorrhage. This observational study focuses on the protein makeup of EVs collected from patients undergoing neurointerventional surgery. Blood samples will be collected from the femoral vein, internal jugular vein, and internal carotid artery during neurointerventional procedures under general anesthesia. The study includes patients with ruptured aneurysms with bleeding confirmed by CT scan and patients with unruptured aneurysms. For those with hemorrhage, blood collection occurs within 3 days of symptom onset. Researchers will analyze the proteins in EVs from these different blood regions to compare their content and explore potential diagnostic and prognostic biomarkers. Participants will undergo blood sampling during their scheduled endovascular surgery, performed between 8:00 AM and 12:00 PM. The study will track proteomic changes in EVs from enrollment through 7 days after treatment. Researchers will also collect clinical information and imaging data to support their analysis. The total involvement includes the surgical procedure and follow-up over the first week, focusing on EV protein characteristics related to aneurysm hemorrhage.
CONDITIONS
Brief Title
Investigation of Protein Heterogeneity in Extracellular Vesicles Derived From Different Human Blood Circulatory Regions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 and 60 years, any gender
- Diagnosed with intracranial aneurysm confirmed by MRA, CTA, or DSA
- For hemorrhagic patients, CT evidence of subarachnoid hemorrhage with blood collection within 3 days of symptom onset
- Scheduled for neurointerventional surgery under general anesthesia starting between 8:00 AM and 12:00 PM
- Willing to follow study procedures and data collection
- Able to understand and sign informed consent
You will not qualify if you...
- Modified Rankin Scale score of 2 or higher before onset or surgery
- Other neurological disorders such as Parkinson's, Alzheimer's, stroke, brain tumors, or epilepsy
- Severe systemic diseases like diabetes, coronary artery disease, cancer, infections, blood diseases, or severe metabolic disorders
- Severe liver or kidney dysfunction (ALT > 3 times normal; creatinine > 225 µmol/L)
- Unable to tolerate anesthesia or anticoagulants, or have coagulation disorders
- History of severe allergic reactions to contrast agents
- Pregnant women
- Participating in other clinical trials without completed follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo neurointerventional surgery during which blood samples are collected from different vascular regions for analysis.
1 surgery visit (in-person)
Duration - Up to 7 days
Participants are observed post-surgery to assess extracellular vesicle protein differences and potential biomarkers.
Daily visits for up to 7 days
Trial Site Locations
Total: 1 location
1
First Hospital of Jilin University
Changchun, Jilin, China, 130000
Actively Recruiting
Research Team
Z
Zheng Wan, Medical Doctor， MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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