Study of Protein Differences in Extracellular Vesicles from Various Blood Vessels in Adults with Intracranial Aneurysms Comparing Patients with and without Brain Bleeding Undergoing Neurointerventional Surgery

What this Trial Is About

Researchers are studying protein differences in extracellular vesicles EVs found in blood from various parts of the body in patients with ruptured or unruptured intracranial aneurysms. The study aims to understand how EV proteins vary between different blood vessels and to find protein markers that may help diagnose and predict outcomes in subarachnoid hemorrhage. This observational study focuses on the protein makeup of EVs collected from patients undergoing neurointerventional surgery. Blood samples will be collected from the femoral vein, internal jugular vein, and internal carotid artery during neurointerventional procedures under general anesthesia. The study includes patients with ruptured aneurysms with bleeding confirmed by CT scan and patients with unruptured aneurysms. For those with hemorrhage, blood collection occurs within 3 days of symptom onset. Researchers will analyze the proteins in EVs from these different blood regions to compare their content and explore potential diagnostic and prognostic biomarkers. Participants will undergo blood sampling during their scheduled endovascular surgery, performed between 800 AM and 1200 PM. The study will track proteomic changes in EVs from enrollment through 7 days after treatment. Researchers will also collect clinical information and imaging data to support their analysis. The total involvement includes the surgical procedure and follow-up over the first week, focusing on EV protein characteristics related to aneurysm hemorrhage.

Investigation of Protein Heterogeneity in Extracellular Vesicles Derived From Different Human Blood Circulatory Regions