Actively Recruiting
Investigation of Protein Heterogeneity in Extracellular Vesicles Derived From Different Human Blood Circulatory Regions
Led by The First Hospital of Jilin University · Updated on 2026-02-27
120
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the protein heterogeneity in extracellular vesicles (EVs) derived from different human blood circulatory regions of patients with ruptured or unruptured intracranial aneurysms. The main objectives are: Reveal the proteomic heterogeneity of EVs in different blood circulatory regions of the human body。 Reveal the proteomic differences of EVs in cerebral feeding arteries and draining veins between patients with aneurysmal subarachnoid hemorrhage and those without hemorrhage. Explore EV-derived protein biomarkers that reflect the diagnosis and prognosis of subarachnoid hemorrhage
CONDITIONS
Official Title
Investigation of Protein Heterogeneity in Extracellular Vesicles Derived From Different Human Blood Circulatory Regions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 and 60 years, regardless of gender
- Diagnosed with intracranial aneurysm confirmed by MRA, CTA, or DSA
- Patients with aneurysmal subarachnoid hemorrhage must have CT evidence of hemorrhage, with blood collected within 3 days of symptom onset
- Scheduled for neurointerventional surgery under general anesthesia starting between 8:00 AM and 12:00 PM
- Willing to follow the study protocol and data collection procedures
- Able to understand and sign informed consent
You will not qualify if you...
- Modified Rankin Scale score 2 or higher before onset or surgery
- Presence of neurological disorders like Parkinson's, Alzheimer's, cerebral infarction, brain tumors, or epilepsy
- Presence of systemic diseases including diabetes, coronary artery disease, cancer, infections, blood disorders, or severe metabolic conditions affecting blood EV evaluation
- Severe liver or kidney dysfunction (ALT more than 3 times normal; creatinine over 225 µmol/L)
- Unable to tolerate anesthesia, anticoagulant therapy, or having coagulation disorders
- History of severe allergic reactions to contrast agents
- Pregnant women
- Currently participating in other clinical trials without completed follow-up
AI-Screening
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Trial Site Locations
Total: 1 location
1
First Hospital of Jilin University
Changchun, Jilin, China, 130000
Actively Recruiting
Research Team
Z
Zheng Wan, Medical Doctor， MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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