Actively Recruiting
Investigation of REcurrence Mechanisms to Adjuvant osimertINib in Radically Resected EGFR-mutated NSCLC Patients
Led by Gruppo Oncologico Italiano di Ricerca Clinica · Updated on 2026-04-22
100
Participants Needed
25
Research Sites
137 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Retrospective-prospective observational multicentric study including radically resected EGFR-mutated NSCLC patients relapsed during or after adjuvant osimertinib, received according to clinical practice
CONDITIONS
Official Title
Investigation of REcurrence Mechanisms to Adjuvant osimertINib in Radically Resected EGFR-mutated NSCLC Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with radically resected IB-IIIA non-small cell lung cancer with EGFR activating mutation
- Treated with adjuvant osimertinib starting from September 2022 according to clinical practice
- Experienced recurrence of disease during or after adjuvant osimertinib therapy
- Availability of tissue and/or liquid biopsy sample collected at the time of recurrence
- Signed informed consent
You will not qualify if you...
- No available tissue and/or liquid biopsy sample collected at the time of recurrence
- Having other synchronous cancers besides NSCLC or any active cancer that required treatment within the past 2 years
- Being involved in the planning or conduct of this study as staff or investigator
AI-Screening
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Trial Site Locations
Total: 25 locations
1
IRCCS Oncologico Giovanni Paolo II
Bari, BA, Italy, 70124
Active, Not Recruiting
2
Asst Papa Giovanni Xxiii Sc Oncologia
Bergamo, BG, Italy, 24127
Not Yet Recruiting
3
UOC di Oncologia Medica IRCCS - Policlinico S. Orsola Malpighi
Bologna, BO, Italy, 40138
Not Yet Recruiting
4
Humanitas Istituto Clinico Catanese Contrada Cubba
Misterbianco, CT, Italy, 95045
Not Yet Recruiting
5
A.S.S.T - Monza Ospedale San Gerardo
Monza, MB, Italy, 20900
Not Yet Recruiting
6
Grande Ospedale Metropolitano Niguarda Ca' Granda
Milan, Michigan, Italy, 20162
Active, Not Recruiting
7
Dip Oncologia-Ematologia - UO Oncologia AOU Policlinico di Modena
Modena, Missouri, Italy, 41124
Active, Not Recruiting
8
Irccs Humanitas Research Hospital
Milan, MI, Italy, 20089
Not Yet Recruiting
9
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
Milan, MI, Italy, 20113
Not Yet Recruiting
10
Ospedale San Raffaele Dipartimento di Oncologia Medica
Milan, MI, Italy, 20132
Not Yet Recruiting
11
European Institute of Oncology IRCCS
Milan, MI, Italy, 20141
Not Yet Recruiting
12
UOC di Oncologia Medica 2 - IOV Istituto Oncologico Veneto
Padova, PD, Italy, 35128
Not Yet Recruiting
13
S.O.C. di Oncologia Medica e dei Tumori Immuno-correlati, Centro di Riferimento Oncologico IRCCS
Aviano, PN, Italy, 33081
Not Yet Recruiting
14
UOC di Oncologia Medica Azienda Ospedaliero-Universitaria di Parma
Parma, PR, Italy, 43126
Not Yet Recruiting
15
U.O.C. Oncologia Medica Azienda Unità Sanitaria Locale della Romagna
Ravenna, RA, Italy, 48100
Actively Recruiting
16
S.C. Oncologia Provinciale, Azienda USL-IRCCS di Reggio Emilia
Reggio Emilia, RE, Italy, 42123
Active, Not Recruiting
17
Fondazione Policlinico Universitario Campus Bio-Medico
Roma, RM, Italy, 00128
Not Yet Recruiting
18
Ifo-Istituto Regina Elena - Oncologia Medica 1
Roma, RM, Italy, 00144
Not Yet Recruiting
19
Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS
Roma, RM, Italy, 00168
Not Yet Recruiting
20
AOU San Luigi Gonzaga - SSD oncologia polmonare
Orbassano, TO, Italy, 10043
Not Yet Recruiting
21
SC Oncologia ASST Sette Laghi "Ospedale di Circolo e Fondazione Macchi "
Varese, VA, Italy, 21100
Not Yet Recruiting
22
"OSPEDALE P. PEDERZOLI" Casa di Cura Privata S.p.A.
Peschiera del Garda, VR, Italy, 37019
Active, Not Recruiting
23
AOU Integrata di Verona - Ospedale Borgo Trento
Verona, VR, Italy, 37126
Not Yet Recruiting
24
Oncologia Clinica Sperimentale Toraco-Polmonare, IRCCS Pascale di Napoli
Naples, Italy, 80131
Not Yet Recruiting
25
A.O.U. "Maggiore della Carita'"- S.C.D.U Oncologia
Novara, Italy, 28100
Not Yet Recruiting
Research Team
A
Alessandro Leonetti, MD
CONTACT
M
Michele Tognetto
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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