Actively Recruiting
Investigation of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients
Led by Weill Medical College of Cornell University · Updated on 2026-05-14
20
Participants Needed
1
Research Sites
288 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators hypothesize that surgical release of the filum terminale (strand of fibrous tissue at the end of the spinal cord) is a more efficacious treatment option for symptomatic relief than medical management in subjects with Occult Tethered Cord Syndrome (OTCS) and that the risks do not outweigh the benefit profile.
CONDITIONS
Official Title
Investigation of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 2 years or older and under 80 years
- Symptoms refractory to medical management for at least 1 year
- Documented Occult Tethered Cord Syndrome with a total score of at least 30 on the OCCULT Grading Scale, including orthopedic abnormalities, central nervous system dysfunction, cutaneous stigmata, urological or bowel dysfunction, lumbosacral anatomy, and tissue integrity disorder
You will not qualify if you...
- Younger than 2 years or older than 80 years
- Radiographic evidence of tethered cord, including low-lying conus at or below L2-3 disc space, thickened filum over 2 mm, fat in filum or lipoma, or distinct adhesion or tethering
- History of Meningocele manqué or Myelomeningocele
- Presence of cutaneous dermal sinus tract markings
- Previous surgery on the lumbar spine
- Previous surgery for spinal dysraphism
- History of prior infection or autoimmune condition of the central nervous system
AI-Screening
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Trial Site Locations
Total: 1 location
1
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
Research Team
C
Cynthia Nguyen
CONTACT
J
Jeffrey Greenfield, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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