Actively Recruiting
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
Led by BeOne Medicines · Updated on 2026-05-12
525
Participants Needed
80
Research Sites
141 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an open-label, multicenter, first-in-human dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-58067 alone, in combination with BG-89894 (discontinued), and in combination with standard of care therapy in participants with advanced solid tumors and with methylthioadenosine phosphorylase (MTAP) deficiency.
CONDITIONS
Official Title
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must sign informed consent and be able to provide written consent
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 or Karnofsky Performance Scale (KPS) score of 70 or higher
- Life expectancy of at least 3 months
- Evidence of homozygous loss or loss of MTAP expression in tumor tissue
- Able to provide tumor sample meeting requirements for MTAP deficiency testing
- Histologically or cytologically confirmed advanced, metastatic, or unresectable solid tumors with disease progression after standard therapy or lack of suitable standard treatment
- Adequate organ function
You will not qualify if you...
- Prior treatment with any MTA-cooperative PRMT5 inhibitor or MAT2A inhibitor
- Active leptomeningeal disease or symptomatic spinal cord compression
- Uncontrollable pleural, pericardial effusion, or ascites requiring frequent drainage
- Any malignancy within 2 years before first study drug dose except the cancer under study or curatively treated local recurrence
- Significantly impaired lung function
- Clinically significant infections
- Serologically active hepatitis B or C infection
- Known HIV infection (treated HIV may be allowed in Phase 1b under criteria)
- High cardiovascular risk factors
- QTcF over 470 ms or risk factors for torsade de pointes
- Unresolved toxicities from prior anticancer therapy
- Inability to swallow or significant gastrointestinal dysfunction
- Pregnant or breastfeeding females
- Participation in another therapeutic clinical trial (observational studies allowed)
AI-Screening
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Trial Site Locations
Total: 80 locations
1
Usc Norris Comprehensive Cancer Center (Nccc)
Los Angeles, California, United States, 90089-1019
Actively Recruiting
2
Adventhealth
Celebration, Florida, United States, 34747-4606
Actively Recruiting
3
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215-5418
Actively Recruiting
4
Washington University School of Medicine
St Louis, Missouri, United States, 63110-1010
Actively Recruiting
5
Nyu Langone Health
New York, New York, United States, 10016-2708
Actively Recruiting
6
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
7
Sidney Kimmel Cancer Center
Philadelphia, Pennsylvania, United States, 19107-4307
Actively Recruiting
8
The University of Texas Md Anderson Cancer Center
Houston, Texas, United States, 77030-4009
Actively Recruiting
9
Next Dallas
Irving, Texas, United States, 75039-2743
Actively Recruiting
10
Next Virginia
Fairfax, Virginia, United States, 22031
Actively Recruiting
11
Blacktown Cancer and Haematology Centre
Blacktown, New South Wales, Australia, NSW 2148
Actively Recruiting
12
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, QLD 4102
Actively Recruiting
13
Monash Health
Clayton, Victoria, Australia, VIC 3168
Actively Recruiting
14
Austin Health
Heidelberg, Victoria, Australia, VIC 3084
Actively Recruiting
15
Linear Clinical Research
Nedlands, Western Australia, Australia, WA 6009
Actively Recruiting
16
The Second Hospital of Anhui Medical University
Hefei, Anhui, China, 230601
Actively Recruiting
17
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
18
Beijing Cancer Hospital
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
19
Beijing Chest Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 101149
Actively Recruiting
20
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China, 400030
Actively Recruiting
21
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Actively Recruiting
22
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China, 361003
Actively Recruiting
23
Sun Yat Sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
24
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)
Guangzhou, Guangdong, China, 510245
Actively Recruiting
25
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China, 510405
Actively Recruiting
26
Meizhou People Hospital
Meizhou, Guangdong, China, 514031
Actively Recruiting
27
Guangxi Medical University Cancer Hospital Wuxiang Branch
Nanning, Guangxi, China, 530201
Actively Recruiting
28
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150000
Actively Recruiting
29
Henan Cancer Hospital
Zhengzhou, Henan, China, 450000
Actively Recruiting
30
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
31
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Actively Recruiting
32
Hubei Cancer Hospital
Wuhan, Hubei, China, 430079
Actively Recruiting
33
Yichang Central Peoples Hospital
Yichang, Hubei, China, 443003
Actively Recruiting
34
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
Actively Recruiting
35
Jiangxi Cancer Hospital
Nanchang, Jiangxi, China, 330029
Actively Recruiting
36
The First Hospital of Jilin University
Changchun, Jilin, China, 130021
Actively Recruiting
37
The First Hospital of China Medical University
Shenyang, Liaoning, China, 110001
Actively Recruiting
38
Shandong Cancer Hospital
Jinan, Shandong, China, 250117
Actively Recruiting
39
The Second Affiliated Hospital of Shandong First Medical University
Taian, Shandong, China, 271099
Actively Recruiting
40
Weifang Peoples Hospital Beichen Branch
Weifang, Shandong, China, 261057
Actively Recruiting
41
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200025
Actively Recruiting
42
Shanghai East Hospital Branch Hospital
Shanghai, Shanghai Municipality, China, 200123
Actively Recruiting
43
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China, 200433
Actively Recruiting
44
Fudan University Shanghai Cancer Centerpudong
Shanghai, Shanghai Municipality, China, 201321
Actively Recruiting
45
Shanxi Provincial Cancer Hospital
Taiyuan, Shanxi, China, 030013
Actively Recruiting
46
Sichuan Cancer Hospitaltianfu Branch
Chengdu, Sichuan, China, 610000
Actively Recruiting
47
Sichuan Cancer Hospital and Institute
Chengdu, Sichuan, China, 610041
Actively Recruiting
48
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
49
Deyangs People Hospital
Deyang, Sichuan, China, 618000
Actively Recruiting
50
Tianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, China, 300060
Actively Recruiting
51
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310003
Actively Recruiting
52
Zhejiang Provincial Peoples Hospital
Hangzhou, Zhejiang, China, 310014
Actively Recruiting
53
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
54
Taizhou Hospital of Zhejiang Provinceenze Branch
Taizhou, Zhejiang, China, 318050
Actively Recruiting
55
Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
56
Centre de Lutte Contre Le Cancer Institut Bergonie
Bordeaux, France, 33000
Actively Recruiting
57
Institut Curie Paris
Paris, France, 75005
Actively Recruiting
58
Institut de Cancerologie de Louest
Saint-Herblain, France, 44800
Actively Recruiting
59
Institut Gustave Roussy
Villejuif, France, 94800
Actively Recruiting
60
Hospital Pulau Pinang
George Town, Malaysia, 10990
Actively Recruiting
61
Hospital Raja Perempuan Zainab Ii
Johor Bahru, Malaysia, 15586
Actively Recruiting
62
Hospital Kuala Lumpur
Kuala Lumpur, Malaysia, 50586
Actively Recruiting
63
University Malaya Medical Centre
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
64
Sarawak General Hospital
Kuching, Malaysia, 93586
Actively Recruiting
65
The Institute of Oncology, Arensia Exploratory Medicine
Chisinau, Moldova, 2025
Actively Recruiting
66
The Catholic University of Korea, St Vincents Hospital
PaldalGu SuwonSi, Gyeonggi-do, South Korea, 16247
Actively Recruiting
67
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
68
Samsung Medical Center
GangnamGu, Seoul Teugbyeolsi, South Korea, 06351
Actively Recruiting
69
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi, South Korea, 03722
Actively Recruiting
70
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 03080
Actively Recruiting
71
Asan Medical Center
SongpaGu, Seoul Teugbyeolsi, South Korea, 05505
Actively Recruiting
72
Hospital Universitario Vall Dhebron
Barcelona, Spain, 08035
Actively Recruiting
73
Start Madrid Fundacion Jimenez Diaz
Madrid, Spain, 28040
Actively Recruiting
74
Hospital Universitario Hm Madrid Sanchinarro
Madrid, Spain, 28050
Actively Recruiting
75
Hospital Clinico San Carlos
Madrid, Spain, 28240
Actively Recruiting
76
Ramathibodi Hospital Mahidol University
Bangkok, Thailand, 10400
Actively Recruiting
77
Siriraj Hospital
Bangkok, Thailand, 10700
Actively Recruiting
78
Songklanagarind Hospital (Prince of Songkhla University)
Hat Yai, Thailand, 90110
Actively Recruiting
79
Srinagarind Hospital (Khon Kaen University)
Muang, Thailand, 40002
Actively Recruiting
80
Maharaj Nakorn Chiang Mai Hospital (Chiang Mai University)
Muang, Thailand, 50200
Actively Recruiting
Research Team
S
Study Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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