Investigational Use of Neuromuscular Ultrasound for Imaging Nerves and Muscles in Adults with and without Neuromuscular Disorders

What this Trial Is About

Researchers are investigating new ultrasound imaging techniques to better observe and understand the structure and function of nerves and muscles. This observational study aims to gather detailed, quantitative data on nerves and muscles, which may serve as useful biomarkers in neuromuscular diseases. The study includes both healthy adults and adults with neuromuscular disorders, focusing on improving current methods used to assess nerve and muscle health. Participants will undergo specialized ultrasound scans using high-resolution probes to measure nerve and muscle properties such as size, stiffness, and blood flow. Various imaging methods including B-mode imaging, shear wave elastography, and microvascular flow assessments will be used. The study collects normal values for these measures in healthy volunteers and compares them with those in participants with neuromuscular conditions. Some participants may also have nerve conduction studies involving mild electrical stimulation to assess nerve function. During up to five outpatient visits lasting less than 3-4 hours each, participants will provide their medical history and have physical exams. Ultrasound scans and nerve conduction studies will be performed to capture images and measurements of nerves, muscles, and diaphragm movement during breathing tests. The study will track reproducibility of imaging techniques and compare ultrasound findings with nerve conduction results. Participants are monitored for safety and must be available for the full study duration, which continues until August 2026.

Investigational Use of Neuromuscular Ultrasound