Actively Recruiting
The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow
Led by Ain Shams University · Updated on 2025-03-11
1000
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this work is to study the role of intracoronary adrenaline administration as a preventive tool for no reflow in patients undergoing primary PCI. The main question it aims to answer is: Do prohylcatic intrcoronary adrenaline reduce the incidence of no reflow without increaing risk of arrhythmia in primary PCI? The procedure will be performed by expert operators. All patients will receive the guidelines-directed recommendations of intervention of STEMI patients. Study group wil receive Intracoronary 10 mcg adrenaline via the guiding catheter after restoration of epicardial coronary flow of the culprit vessel and achievement of TIMI I flow either after wiring and/or passage of a deflated balloon and/or PTCA with a small balloon, and/or use of thrombus aspiration and before stenting. All steps in the Cath-lab will be described in detail: The primary end points will be improvement in coronary flow, as assessed by TIMI (Thrombolysis in Myocardial Infarction) flow, and myocardial blush. Secondary end points will be in-hospital mortality and major adverse cardiac events.
CONDITIONS
Official Title
The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who are 18 years or older
- Patients presenting with acute coronary syndrome with ECG criteria diagnostic of STEMI within 12 hours from symptom onset
- Patients treated by successful primary PCI
You will not qualify if you...
- Age under 18 years
- Pregnant females
- Patients who refused to give consent
- Patients with normal coronary angiography
- Patients with chronic total occlusion (CTO) lesions
- Patients with spontaneous coronary artery dissection (SCAD)
- Patients who developed dissection or mechanical complications during the procedure
- Patients presenting with cardiogenic shock
- Patients with cardiomyopathies
- Contraindications to epinephrine, including hypertension with systolic blood pressure over 180 mmHg or diastolic over 110 mmHg, significant arrhythmias prior to PCI, or known allergy to epinephrine
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of medicine Ain Shams Univesity
Cairo, Egypt
Actively Recruiting
Research Team
M
Mostafa Abdallah Khalifa, Master cardiology
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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