Actively Recruiting
An Investigator-initiated Linked Study to OCEANIC-AF
Led by East and North Hertfordshire NHS Trust · Updated on 2023-11-09
100
Participants Needed
2
Research Sites
149 weeks
Total Duration
On this page
Sponsors
E
East and North Hertfordshire NHS Trust
Lead Sponsor
L
Liverpool Heart and Chest Hospital NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Impaired endogenous fibrinolysis is a recently recognised risk factor for thrombotic events in patients with cardiovascular disease. Enhancing endogenous fibrinolysis in such individuals represents a way of reducing thrombosis risk. However, the optimal pharmacotherapy to enhance fibrinolysis is unclear. The aim of this study is to assess the effect of asundexian on endogenous fibrinolysis and compare this to apixaban. If asundexian can enhance endogenous fibrinolysis, this could be used as targeted treatment for patients who despite optimal antithrombotic therapy, demonstrate impaired endogenous fibrinolysis.
CONDITIONS
Official Title
An Investigator-initiated Linked Study to OCEANIC-AF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or over
- Patients enrolled in OCEANIC-AF study
- Free from the exclusion criteria
- Able and willing to understand the Patient Information Sheet and provide written informed consent
- Agree to have blood samples drawn for assessments
You will not qualify if you...
- Unable to provide valid informed consent
- Patients under 18 years of age
- Significant neurological, hepatic, renal, endocrine, gastrointestinal, pulmonary, hemorrhagic, metabolic, or other diseases likely to affect the study
- History or signs of substance abuse or active psychiatric disease
- Alcohol consumption above 21 units per week
- Any significant illness in the 4 weeks before screening
- Major bleeding disorders or blood abnormalities as defined by specific blood test thresholds
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom
Not Yet Recruiting
2
East and North Herts NHS Trust
Stevenage, United Kingdom
Actively Recruiting
Research Team
J
Joshua H Leader, MBCHB, BSc
CONTACT
D
Diana A Gorog, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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