Actively Recruiting
Investigator Initiated Study to Assess the Safety of Combination of CLS-015 With Anti-CD-19 CAR-T Cells in Patients With Stable/Progressive Large B Cell Lymphoma at Lymphodepletion.
Led by Tel-Aviv Sourasky Medical Center · Updated on 2026-05-01
12
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 1, single-center, open-label study to evaluate the safety of CLS-015 in combination with anti-CD19 CAR-T therapy in patients with large B-cell lymphoma. The goal is to improve clinical response by reversing the negative effects of NETs on immune function and CAR-T cells.
CONDITIONS
Official Title
Investigator Initiated Study to Assess the Safety of Combination of CLS-015 With Anti-CD-19 CAR-T Cells in Patients With Stable/Progressive Large B Cell Lymphoma at Lymphodepletion.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be at least 18 years old at the time of consent
- Diagnosed with large B-cell lymphoma treated with CAR-T therapy targeting CD19 (tisagenlecleucel, axicabtagene ciloleucel, or lisocabtagene maraleucel)
- Have stable disease or progressive disease confirmed by PET-CT on the day of lymphodepletion
- Able to provide signed informed consent
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
You will not qualify if you...
- Allergic reaction or hypersensitivity to CLS-015
- Any clinically significant condition or disease that poses risk to safety or interferes with study participation, as judged by the investigator
- Active infection that requires antibiotic treatment
- Pregnant or breastfeeding females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sourasky Medical Center
Tel Aviv, Israel, 6423906
Actively Recruiting
Research Team
R
Ron Ram, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here