Actively Recruiting
Involvement of Archaea in Carious Disease
Led by Assistance Publique Hopitaux De Marseille · Updated on 2026-02-23
200
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dental caries is a major public health probleme the result of hard tissue demineralization and oral microbiota changes. Methanogenic archaea, mainly Methanobrevibacter oralis, are associated with various oral problems, including pathologies periodontal. Previous research has not really studied the Archaea in carious lesions, hence the importance of our study. Our study aims to explore their potential role in the the development of caries by analysing their prevalence and their quantification in relation to the carious risk individual. The aim is to improve understanding of the Cavity microbiology to advance management of this pathology in terms of prevention or of treatment. Our team is particularly competent in the field of Archaea, especially in the cultivation of Archaea methanogens since we have a dedicated platform. We also discovered the first human Nanoarchaea, opening up a whole new possible search field.
CONDITIONS
Official Title
Involvement of Archaea in Carious Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female of legal age
- Patient who is a beneficiary or entitled beneficiary of a social security
- Patient under the care of the Restorative and Preventive Dentistry of the PROMOD - Timone Dentistry Unit
- Patients capable of giving written consent
You will not qualify if you...
- Currently participating in another research protocol at the time of consent
- Subjects covered by articles L1121-5 to 1121-8 of the Public Health code (minors, adults under guardianship, deprived of liberty, pregnant or breastfeeding)
- Insufficient ability to read and understand French to consent
- Presence of periodontitis (gingivitis is allowed)
- Antibiotic use in the previous month
- Use of mouthwash in the previous 7 days
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Asssistance Publique Hopitaux de Marseille
Marseille, France, 13354
Actively Recruiting
Research Team
G
Giuliani alexandra project manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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