Study of Effects of Increased Eye Pressure on the Lamina Cribrosa in Healthy and Glaucoma Patients

What this Trial Is About

Researchers are investigating the process that leads to damage in glaucoma, focusing on how increased intraocular pressure IOP affects vision loss. The study aims to better understand the role of the lamina cribrosa LC and the optic nerve head ONH in glaucoma development. This research is prospective and evaluates how the eye tissues respond mechanically to changes in IOP. In this study, the pressure inside the eye will be briefly raised using a device called an ophthalmodynamometer. Participants include healthy volunteers, glaucoma suspects, and those with glaucoma. Researchers will use optical coherence tomography imaging to measure changes in the shape and position of the optic nerve and lamina cribrosa during pressure elevation. These measurements quantify tissue deformation in microns. Participants will undergo eye imaging and pressure tests lasting about 10 minutes each to assess tissue response. The study monitors the deformation of the lamina cribrosa in healthy, suspect, and glaucomatous eyes. There is no randomization or blinding involved. The study involves a single visit with brief pressure elevation and imaging to collect data. Safety and eye health will be closely observed throughout the procedure.

IOP Elevation Study