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Iron Absorption From IFA and MMS Supplements in Kenyan Women During the Second Trimester of Pregnancy
Led by ETH Zurich · Updated on 2026-02-27
50
Participants Needed
2
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates iron absorption from three antenatal supplements, 30 mg MMS, 60 mg MMS, and 60 mg IFA, in 50 pregnant Kenyan women in their second trimester. Using a randomized crossover design and stable iron isotopes, we will compare bioavailability in both fasted and fed states. Additionally, the trial will investigate if daily dosing triggers a hepcidin response that inhibits subsequent absorption, testing whether alternate-day dosing is a more effective strategy for treating iron deficiency.
CONDITIONS
Official Title
Iron Absorption From IFA and MMS Supplements in Kenyan Women During the Second Trimester of Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Pregnant with gestational age 12 (±1) weeks confirmed by ultrasound
- Age between 18 and 35 years
- Hemoglobin concentration of 80 g/L or higher
- No significant inflammation
- Body weight less than 80 kg
- No major chronic diseases
- No use of vitamin and mineral supplements outside this study during the 1-2 weeks between screening and study start and during the study
- No blood transfusion, blood donation, or significant blood loss in the past 4 months
You will not qualify if you...
- Severe anemia (hemoglobin less than 80 g/L)
- Malaria
- Sickle cell disease (types SS and SC)
- Hemoglobin C disease (type CC)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Kwale Sub County Hospital
Kwale, Kwale County, Kenya
Actively Recruiting
2
Msambweni County Referral Hospital
Msambweni, Kwale County, Kenya
Actively Recruiting
Research Team
L
Laura N Wasserfallen, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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