Actively Recruiting
Iron Replacement to Reduce Anemia During Neoadjuvant Chemotherapy
Led by Fox Chase Cancer Center · Updated on 2025-03-11
34
Participants Needed
1
Research Sites
202 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an open-label, single institution study evaluating the efficacy of intravenous iron sucrose monotherapy in patients with thoracic, breast, GU and GI malignancies undergoing neoadjuvant chemotherapy with the goal of undergoing surgical resection.
CONDITIONS
Official Title
Iron Replacement to Reduce Anemia During Neoadjuvant Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients older than 18 years
- Undergoing neoadjuvant chemotherapy, including radiation and/or immunotherapy, with intent for curative surgical resection for breast, thoracic, gastrointestinal (GI), or genitourinary (GU) cancers
- Anemia defined as hemoglobin less than 10.5 g/dL during chemotherapy
- Iron storage levels with ferritin less than 500 ng/mL and iron saturation less than 35%
- Ability to understand and willing to sign informed consent and HIPAA consent documents
You will not qualify if you...
- Anemia with hemoglobin less than 11.0 g/dL at cycle 1 day 1 of neoadjuvant chemotherapy
- Uncontrolled illness such as active infection, symptomatic congestive heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social conditions limiting compliance
- Prior intravenous iron infusion within 4 weeks
- Use of erythropoietin stimulating agents within 4 weeks unless for chronic kidney disease
- Concurrent systemic infection at enrollment
- Known allergy to iron sucrose
- Pregnant or breastfeeding
- Anemia from other known causes such as myelodysplastic syndrome or myeloma
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Actively Recruiting
Research Team
R
Ryan Romasko
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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