Actively Recruiting
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
Led by Medical College of Wisconsin · Updated on 2025-09-23
60
Participants Needed
1
Research Sites
343 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise. Participants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or high pressure for 2 weeks at home. Participants will repeat the same steps in Study Visit 2 for Study Visit 3. In addition, participants will also be assessed for their frailty and physical function.
CONDITIONS
Official Title
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women and men ages 65-85 years of age
You will not qualify if you...
- Myocardial infarction in last 6 months
- Morbid obesity (BMI >40)
- Heart failure
- Uncontrolled hypertension
- Other conditions that prevent high intensity exercise (e.g., neurological disorder, acute systemic infection)
- History of blood clots in the extremities
- Any condition where arm compression or transient ischemia is not safe (e.g., wounds on the arm)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Froedtert Hospital
Wauwatosa, Wisconsin, United States, 53226
Actively Recruiting
Research Team
J
Jennifer Nguyen
CONTACT
M
Matt Durand
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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