Actively Recruiting
Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke
Led by Ming Wei · Updated on 2024-06-13
200
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Post-ischemic adaptation is a physical brain protective treatment strategy in which an ischemic event in an organ or tissue is treated and blood flow is restored, and an ischemic stimulus is given to local tissues to induce the production of anti-ischemic damage factors and reduce the damage associated with reperfusion therapy . Relevant basic studies have confirmed that post-ischemic adaptation can reduce infarct volume and promote neurological function recovery in animal models of cerebral infarction. Therefore, it may be beneficial to the recovery of neurological function in patients with acute ischemic stroke undergoing mechanical thrombus extraction. Based on the above background, the use of a balloon to repeatedly dilate-contract at the original occlusion site after revascularization to block and restore arterial flow may be an effective cerebroprotective treatment for patients with large-vessel occlusion who undergo thrombolysis. However, can this approach be safely used in patients with acute ischemic stroke treated with thrombolysis? What is the protocol for the length of time patients can tolerate post-ischemic adaptation? The application of this method in the treatment of acute ischemic stroke will be explored in this study.
CONDITIONS
Official Title
Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 1)Ischemic stroke confirmed by CT or MRI of the head;
- 2) Large vessel occlusion confirmed by CTA or MRA of the head, including: intracranial internal carotid artery (ICA), middle cerebral artery (MCA M1/M2), anterior cerebral artery (ACA A1/A2), basilar artery (BA), vertebral artery (VA), and posterior cerebral artery (PCA P1/P2);
- 3) Recanalization of the occluded vessel at eTICI grade 2b/3 as confirmed by DSA after thrombectomy;
- 4)The patient/legally authorized representative has signed an informed consent form.
You will not qualify if you...
- 1) Inability to perform an MRI or CT scan for any reason;
- 2）The patient has any condition that would interfere with neurologic assessment or psychiatric disorders;
- 3）Stroke onset with seizures resulted in the inability to obtain an accurate NIHSS baseline;
- 4）Pregnancy
- 5）Other serious, advanced or terminal illness;
AI-Screening
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Trial Site Locations
Total: 1 location
1
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China
Actively Recruiting
Research Team
M
Ming Wei, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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