Actively Recruiting
iTBS for Increased Appetite Induced by Antipsychotics
Led by Central South University · Updated on 2025-03-26
60
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Antipsychotics are prone to cause metabolic side effects, including weight gain, hyperglycemia, insulin resistance, hyperlipidemia and so on, leading to a 2-3 times higher risk of death in patients with schizophrenia compared to healthy people. Conventional high-frequency rTMS have been used to treat people with obesity and showed certain effectiveness. However, studies involving schizophrenia patients and intermittent theta burst (iTBS) mode are rarely seen. The goal of this clinical trial is to evaluate the efficacy and safety of iTBS on ameliorating increased appetite induced by antipsychotics in people with schizophrenia.
CONDITIONS
Official Title
iTBS for Increased Appetite Induced by Antipsychotics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 40 years old
- Diagnosis of schizophrenia according to DSM-5
- Body mass index (BMI) of 25 kg/m2 or higher or more than 10% weight gain after antipsychotic use in the last year
- No transcranial magnetic stimulation (TMS) therapy in the past month
- Use of no more than two antipsychotic medications without antidepressants or mood stabilizers; short-term use of benzodiazepines, benzhexol, and propranolol allowed
- Signed written informed consent voluntarily
You will not qualify if you...
- Other severe mental illnesses, mental retardation, dementia, or severe cognitive impairment
- Abnormal brain structure or function due to major physical or neurological disease or traumatic brain injury
- Presence of metallic implants, pacemakers, history of epilepsy, or other contraindications for TMS
- Suicidal thoughts or behaviors
- Alcohol or substance abuse
- Pregnant or lactating women
- Contraindications for MRI
- Regular modified electroconvulsive therapy (MECT) or weight-loss therapy in the past month
- Any other abnormal examination results deemed inappropriate by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Central South University
Changsha, Hunan, China, 410000
Not Yet Recruiting
2
The Second People's Hospital of Dali Bai Autonomous Prefecture
Dali, Yunnan, China, 671014
Actively Recruiting
Research Team
R
Renrong Wu, M.D. Ph.D
CONTACT
J
Jing Huang, M.D. Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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